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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/44595

    Título
    High blood pressure associates with the remodelling of inward rectifier K+ channels in mice mesenteric vascular smooth muscle cells
    Autor
    Tajada Esteban, SendoaAutoridad UVA
    Cidad Velasco, María Del PilarAutoridad UVA Orcid
    Moreno Domínguez, Alejandro
    Pérez García, María TeresaAutoridad UVA Orcid
    López López, José RamónAutoridad UVA Orcid
    Año del Documento
    2012
    Editorial
    The Physiological Society
    Descripción
    Producción Científica
    Documento Fuente
    The Journal of Physiology, 2012, vol. 590, n. 23. p. 6075-6091
    Abstract
    The increased vascular tone that defines essential hypertension is associated with depolarization of vascular smooth muscle cells (VSMCs) and involves a change in the expression profile of ion channels promoting arterial contraction. As a major regulator of VSMC resting membrane potential (VM), K+channel activity is an important determinant of vascular tone and vessel diameter. However, hypertension-associated changes in the expression and/or modulation of K+channels are poorly defined, due to their large molecular diversity and their bed-specific pattern of expression. Moreover, the impact of these changes on the integrated vessel functionand their contribution to the development of altered vascular tone under physiological conditions need to be confirmed. Hypertensive (BPH) and normotensive (BPN) mice strains obtained by phenotypic selection were used to explore whether changes in the functional expression of VSMC inward rectifier K+channels contribute to the more depolarized resting VM and the increased vascular reactivity of hypertensive arteries. We determined the expression levels of inward rectifierK+channel mRNA in several vascular beds from BPN and BPH animals, and their functional contribution to VSMC excitability and vascular tone in mesenteric arteries. We found a decrease in the expression of Kir2.1, Kir4.1, Kir6.x and SUR2 mRNA in BPH VSMCs, and a decreased functional contribution of both KIRand KATP channels in isolated BPH VSMCs. However, only the effect of KATP channel modulators was impaired when exploring vascular tone, suggesting that decreased functional expression of KATP channels may be an important element in the remodelling of VSMCs in essential hypertension.
    Materias Unesco
    32 Ciencias Médicas
    Palabras Clave
    Hypertension
    Hipertensión
    Vascular smooth muscle
    Músculo liso vascular
    ISSN
    1469-7793
    Revisión por pares
    SI
    DOI
    10.1113/jphysiol.2012.236190
    Patrocinador
    Ministerio de Sanidad, Consumo y Bienestar Social - Instituto de Salud Carlos III (grant R006/009)
    Ministerio de Ciencia, Innovación y Universidades (grant BFU2010-15898)
    Junta de Castilla y León (grant VA094A11-2)
    Version del Editor
    https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.2012.236190
    Propietario de los Derechos
    © 2012 The Journal of Physiology
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/44595
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Collections
    • DEP06 - Artículos de revista [352]
    • IBGM - Artículos de revista [78]
    • VASCUMIT - Artículos de revista [47]
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    Universidad de Valladolid

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