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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/44607

    Título
    Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism
    Autor
    Cidad Velasco, María Del PilarAutoridad UVA Orcid
    Jiménez Pérez, Laura
    García Arribas, Daniel
    Miguel Velado, Eduardo
    Tajada Esteban, SendoaAutoridad UVA
    Ruiz McDavitt, Christian
    López López, José RamónAutoridad UVA Orcid
    Pérez García, María TeresaAutoridad UVA Orcid
    Año del Documento
    2012
    Editorial
    American Heart Association
    Descripción
    Producción Científica
    Documento Fuente
    Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, vol. 32, n. 5. p. 1299-1307
    Zusammenfassung
    Objective: Phenotypic modulation of vascular smooth muscle cells has been associated with a decreased expression of all voltage-dependent potassium channel (Kv)1 channel encoding genes but Kcna3 (which encodes Kv1.3 channels). In fact, upregulation of Kv1.3 currents seems to be important to modulate proliferation of mice femoral vascular smooth muscle cells in culture. This study was designed to explore if these changes in Kv1 expression pattern constituted a landmark of phenotypic modulation across vascular beds and to investigate the mechanisms involved in the proproliferative function of Kv1.3 channels. Methods and Results: Changes in Kv1.3 and Kv1.5 channel expression were reproduced in mesenteric and aortic vascular smooth muscle cells, and their correlate with protein expression was electrophysiologicaly confirmed using selective blockers. Heterologous expression of Kv1.3 and Kv1.5 channels in HEK cells has opposite effects on the proliferation rate. The proproliferative effect of Kv1.3 channels was reproduced by “poreless” mutants but disappeared when voltagedependence of gating was suppressed. Conclusion: These findings suggest that the signaling cascade linking Kv1.3 functional expression to cell proliferation is activated by the voltage-dependent conformational change of the channels without needing ion conduction. Additionally, the conserved upregulation of Kv1.3 on phenotypic modulation in several vascular beds makes this channel a good target to control unwanted vascular remodeling.
    Palabras Clave
    Gene expression
    Expresión génica
    Ion channels
    Canales iónicos
    Vascular smooth muscle
    Músculo liso vascular
    Cell proliferation
    Proliferación celular
    ISSN
    1524-4636
    Revisión por pares
    SI
    DOI
    10.1161/ATVBAHA.111.242727
    Patrocinador
    Instituto de Salud Carlos III (grant R006/009)
    Ministerio de Ciencia, Innovación y Universidades (grant BFU2010-15898)
    Junta de Castilla y León (grant VA094A11-2)
    Version del Editor
    https://www.ahajournals.org/doi/10.1161/ATVBAHA.111.242727
    Propietario de los Derechos
    © 2012 American Heart Association
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/44607
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [353]
    • IBGM - Artículos de revista [79]
    • VASCUMIT - Artículos de revista [47]
    Zur Langanzeige
    Dateien zu dieser Ressource
    Nombre:
    Kv1.3-channels-can-modulate.pdf
    Tamaño:
    3.104Mb
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    Universidad de Valladolid

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