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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/45019

    Título
    Sarcoplasmic reticulum Ca2+ decreases with age and correlates with the decline in muscle function in Drosophila
    Autor
    Río Lorenzo, Alba delAutoridad UVA Orcid
    Rojo Ruiz, JonatanAutoridad UVA Orcid
    Alonso Alonso, María TeresaAutoridad UVA
    García-Sancho Martín, Francisco JavierAutoridad UVA Orcid
    Año del Documento
    2020
    Editorial
    The Company of Biologists
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Cell Science, 2020, vol. 133, n. 6. 9 p.
    Zusammenfassung
    Sarcopenia, the loss of muscle mass and strength associated with age, has been linked to impairment of the cytosolic Ca2+ peak that triggers muscle contraction, but mechanistic details remain unknown. Here we explore the hypothesis that a reduction in sarcoplasmic reticulum (SR) Ca2+ concentration ([Ca2+]SR) is at the origin of this loss of Ca2+ homeostasis. We engineered Drosophila melanogaster to express the Ca2+ indicator GAP3 targeted to muscle SR, and we developed a new method to calibrate the signal into [Ca2+]SR in vivo. [Ca2+]SR fell with age from ∼600 µM to 50 µM in close correlation with muscle function, which declined monotonically when [Ca2+]SR was <400 µM. [Ca2+]SR results from the pump-leak steady state at the SR membrane. However, changes in expression of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump and of the ryanodine receptor leak were too modest to explain the large changes seen in [Ca2+]SR. Instead, these changes are compatible with increased leakiness through the ryanodine receptor as the main determinant of the [Ca2+]SR decline in aging muscle. In contrast, there were no changes in endoplasmic reticulum [Ca2+] with age in brain neurons.
    Palabras Clave
    Calcium homeostasis
    Homeostasis del calcio
    Drosophila melanogaster
    Endoplasmic reticulum
    Retículo endoplasmático
    Sarcopenia
    Sarcoplasmic reticulum
    Retículo sarcoplasmático
    ISSN
    1477-9137
    Revisión por pares
    SI
    DOI
    10.1242/jcs.240879
    Patrocinador
    Ministerio de Economía, Industria y Competitividad (grant BFU2017-83066-P)
    Junta de Castilla y León (project GR175)
    Version del Editor
    https://jcs.biologists.org/content/133/6/jcs240879
    Propietario de los Derechos
    © 2020 The Company of Biologists
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/45019
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • CFC - Artículos de Revista [38]
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    Dateien zu dieser Ressource
    Nombre:
    Sarcoplasmic-reticulum-Ca2.pdf
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    1.442Mb
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