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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/45077

    Título
    Multi-responsiveness of single anterior pituitary cells to hypothalamic-releasing hormones: A cellular basis for paradoxical secretion
    Autor
    Villalobos Jorge, Carlos
    Núñez Llorente, LucíaAutoridad UVA
    Frawley, L. Stephen
    García-Sancho Martín, Francisco JavierAutoridad UVA Orcid
    Sánchez, Ana
    Año del Documento
    1997
    Editorial
    National Academy of Sciences
    Descripción
    Producción Científica
    Documento Fuente
    Proceedings of the National Academy of Sciences of the United States of America, 1997, vol. 94, n. 25. p. 14132-14137
    Abstract
    The classic view for hypothalamic regulation of anterior pituitary (AP) hormone secretion holds that release of each AP hormone is controlled specifically by a corresponding hypothalamic-releasing hormone (HRH). In this scenario, binding of a given HRH (thyrotropin-, growth hormone-, corticotropin-, and luteinizing hormone-releasing hormones) to specific receptors in its target cell increases the concentration of cytosolic Ca2+ ([Ca2+]i), thereby selectively stimulating the release of the appropriate hormone. However, “paradoxical” responses of AP cells to the four well-established HRHs have been observed repeatedly with both in vivo and in vitro systems, raising the possibility of functional overlap between the different AP cell types. To explore this possibility, we evaluated the effects of HRHs on [Ca2+]i in single AP cells identified immunocytochemically by the hormone they stored. We found that each of the five major AP cell types contained discrete subpopulations that were able to respond to several HRHs. The relative abundance of these multi-responsive cells was 59% for lactotropes, 33% for thyrotropes, and in the range of 47–55% for gonadotropes, corticotropes, and somatotropes. Analysis of prolactin release from single living cells revealed that each of the four HRHs tested were able to induce hormone release from a discrete lactotrope subpopulation, the size of which corresponded closely to that in which [Ca2+]i changes were induced by the same secretagogues. When viewed as a whole, our diverse functional measurements of multi-responsiveness suggest that hypothalamic control of pituitary function is more complicated than previously envisioned. Moreover, they provide a cellular basis for the so-called “paradoxical” behavior of pituitary cells to hypothalamic hypophysiotropic agents.
    Palabras Clave
    Calcium
    Calcio
    Growth hormone
    Hormona del crecimiento
    Prolactin
    Prolactina
    ISSN
    1091-6490
    Revisión por pares
    SI
    DOI
    10.1073/pnas.94.25.14132
    Patrocinador
    Dirección General de Investigación Científica y Técnica (grant PB92-0268)
    National Institutes of Health (grant DK38251)
    Version del Editor
    https://www.pnas.org/content/94/25/14132
    Propietario de los Derechos
    © 1997 National Academy of Sciences
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/45077
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • CFC - Artículos de Revista [38]
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