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Título
Biomechanical changes after in vivo collagen cross-linking with rose bengal–green light and riboflavin-UVA
Autor
Año del Documento
2017
Editorial
Association for Research in Vision and Ophthalmology
Descripción
Producción Científica
Documento Fuente
Investigative Ophthalmology & Visual Science, 2017, vol. 58, n. 3. p. 1612-1620
Abstract
Purpose: To compare corneal biomechanical properties after in vivo and ex vivo cross-linking (CXL) using rose bengal–green light (RGX) or riboflavin-UVA (UVX).
Methods: Corneas of 30 rabbits were treated in vivo by the two CXL modalities monolaterally (Group 1) or bilaterally (Group 2). Rabbits in Group 1 were euthanized 1 month after treatments and in Group 2 two months after treatment. Ex vivo CXL was also performed. Eyes were measured by Scheimpflug air puff corneal deformation imaging (Corvis ST) under constant IOP. Corneal deformation parameters were assessed. Inherent corneal biomechanical properties were estimated using inverse finite element modeling.
Results: Peak to peak distance decreased 16% 2 months after RGX, and 4% and 20% 1 and 2 months after UVX, respectively. The equivalent Young's modulus (Eeq) increased relative to the control during the post treatment period for both RGX and UVX. The Eeq increased by factors of 3.4 (RGX) and 1.7 (UVX) 1 month and by factors of 10.7 (RGX) and 7.3 (UVX) 2 months after treatment. However, the Eeq values for ex vivo CXL were much greater than produced in vivo. The ex vivo Eeq was greater than the 1-month in vivo values by factors of 8.1 (RGX) and 9.1 (UVX) and compared with 2 month by factors of 2.5 (RGX) and 2.1 (UVX).
Conclusions: These results indicate that corneal stiffness increases after CXL, and further increases as a function of time after both RGX and UVX. Also, while biomechanical properties determined after ex vivo CXL are indicative of corneal stiffening, they may not provide entirely accurate information about the responses to CXL in vivo.
Materias Unesco
2209.15 Optometría
Palabras Clave
Corneal biomechanics
Biomecánica corneal
Cross-linking technique
Técnica de cross-linking
Inverse model
Modelo inverso
Computational model
Modelo computacional
ISSN
1552-5783
Revisión por pares
SI
Patrocinador
Consejo Europeo de Investigación (grant ERC-2011-AdC-294099)
Comunidad de Madrid - Marie Curie COFUND program (grant FP7/2007-2013/REA 291820)
Gobierno de España (grant FIS2014-56643-R)
Comunidad de Madrid - Marie Curie COFUND program (grant FP7/2007-2013/REA 291820)
Gobierno de España (grant FIS2014-56643-R)
Version del Editor
Propietario de los Derechos
© 2017 Association for Research in Vision and Ophthalmology
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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