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dc.contributor.author | Treviño, Ana | |
dc.contributor.author | Soriano, Vincent | |
dc.contributor.author | Poveda, Eva | |
dc.contributor.author | Parra, Patricia | |
dc.contributor.author | Cabezas, Teresa | |
dc.contributor.author | Caballero, Estrella | |
dc.contributor.author | Roc, Lourdes | |
dc.contributor.author | Rodríguez, Carmen | |
dc.contributor.author | Eiros Bouza, José María | |
dc.contributor.author | López, Mariola | |
dc.contributor.author | Mendoza, Carmen de | |
dc.date.accessioned | 2021-03-23T12:11:41Z | |
dc.date.available | 2021-03-23T12:11:41Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Journal of Antimicrobial Chemotherapy, 2014, vol. 69, n. 8, p. 2191-2194 | es |
dc.identifier.issn | 0305-7453 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/45935 | |
dc.description | Producción Científica | es |
dc.description.abstract | Background:HIV-2 infection is characterized by low plasma viraemia and slower progression to AIDS in compari-son with HIV-1 infection. However, antiretroviral therapy in patients with HIV-2 is less effective and often fails toprovide optimal CD4 recovery.Methods:We examined viral tropism in persons with HIV-2 infection enrolled in the HIV-2 Spanish cohort. Viraltropism was estimated based on V3 sequences obtained from plasma RNA and/or proviral DNA.Results:From a total of 279 individuals with HIV-2 infection recorded in the Spanish national register, 58 V3sequences belonging to 42 individuals were evaluated. X4 viruses were recognized in 14 patients (33%).Patients with X4 viruses had lower median CD4+cell counts than patients with R5 viruses [130 (17 – 210) versus359 (180 – 470) cells/mm3;P¼0.007]. This was true even considering only the subset of 19 patients on antiretro-viral therapy [94 (16 – 147) versus 184 (43 – 368) cells/mm3;P¼0.041]. In multivariate analysis, significant differ-ences in CD4+cell counts between patients with X4 and R5 viruses remained after adjusting for age, gender,antiretroviral therapy and viral load.Conclusions:The presence of X4-tropic viruses in HIV-2 infection is associated with low CD4+cell counts, regard-less of antiretroviral treatment. Along with CD4+cell counts, viral tropism testing may assist decisions aboutwhen to initiate antiretroviral therapy in HIV-2-infected individuals. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Oxford University Press | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.classification | Antagonistas | es |
dc.subject.classification | Carga proviral | es |
dc.subject.classification | Maraviroc | es |
dc.title | HIV-2 viral tropism influences CD4+ T cell count regardless of viral load | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © Oxford University Press | es |
dc.identifier.doi | 10.1093/jac/dku119 | es |
dc.relation.publisherversion | https://academic.oup.com/jac/article/69/8/2191/2911286 | es |
dc.identifier.publicationfirstpage | 2191 | es |
dc.identifier.publicationissue | 8 | es |
dc.identifier.publicationlastpage | 2194 | es |
dc.identifier.publicationtitle | Journal of Antimicrobial Chemotherapy | es |
dc.identifier.publicationvolume | 69 | es |
dc.peerreviewed | SI | es |
dc.description.project | Fundación Investigación y Educación en Sida. (RIS, ISCIII-RETICRD/12/0017/0031) | es |
dc.description.project | Fondo de Investigación Sanitaria (FIS, PI10/00520) | es |
dc.description.project | Ministerio de Salud Consumo y Bienestar Social (EC10/277) | es |
dc.description.project | Ministerio de Ciencia e Innovación (MICINN, SAF2010/22232) | es |
dc.description.project | El proyecto Europeo CHAIN (FP7-223131) | es |
dc.identifier.essn | 1460-2091 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
dc.subject.unesco | 32 Ciencias Médicas | es |
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