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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/4632

    Título
    Role of interleukin 1B in the control of neuropithelial proliferation and differentiation of the spinal cord during development
    Autor
    Mano Bonín, Anibal de laAutoridad UVA
    Gato Casado, Ángel LuisAutoridad UVA Orcid
    Alonso Revuelta, María IsabelAutoridad UVA Orcid
    Carnicero Gila, Estela MaríaAutoridad UVA Orcid
    Martín, C.
    Moro Balbás, José AntonioAutoridad UVA Orcid
    Año del Documento
    2007
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Citokine, vol. 37. p.128-137
    Résumé
    Interleukin-1b (IL-1b) is an important trophic factor in the nervous system (NS). IL-1b is ubiquitously expressed from very early stages during the development of the amphibian NS and its action has been demonstrated in vitro on survival, proliferation and differ- entiation in mammalian embryos. In this report, we show that IL-1b is immunocytochemically expressed in embryonic spinal cord from early stages, both in rat (embryonic day 12) and in chicken (stage 17-HH), in neuroepithelial cells and nerve fibres, dorsal root ganglia, anterior and posterior roots of the spinal nerves, and in the fibres of these nerves. Our in vivo experiments on chick embryos, with micro- beads impregnated with IL-1b implanted laterally to the spinal cord at the level of the wing anlage, demonstrate that this cytokine pro- duces a statistically significant increase in nuclear incorporation of BrdU at the dorsal level and a reduction of this at the ventral level, whereas local immunoblocking with anti-IL-1b antibodies causes a dorsal reduction of BrdU incorporation and alters ventral differen- tiation. These data demonstrate that IL-1b plays a part in controlling proliferation and early differentiation during the development of the spinal cord in chick embryos.
    Materias (normalizadas)
    Embriología
    Nervioso, Sistema - Enfermedades
    ISSN
    1043-4666
    Revisión por pares
    SI
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/4632
    Derechos
    openAccess
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    • DEP04 - Artículos de revista [57]
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    Gato11.pdf
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

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