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Título
The autoimmunity risk variant LYP-W620 cooperates with CSK in the regulation of TCR signaling
Autor
Año del Documento
2013
Editorial
Public Library of Science
Descripción
Producción Científica
Documento Fuente
PLoS ONE, 2013, vol. 8, n. 1, p. e54569
Abstract
The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus. This polymorphism changes an R by a W in the P1 Pro rich motif of LYP, which binds to CSK SH3 domain, another negative regulator of TCR signaling. Based on the analysis of the mouse homologue, Pep, it was proposed that LYP and CSK bind constitutively to inhibit LCK and subsequently TCR signaling. The detailed study of LYP/CSK interaction, here presented, showed that LYP/CSK interaction was inducible upon TCR stimulation, and involved LYP P1 and P2 motifs, and CSK SH3 and SH2 domains. Abrogating LYP/CSK interaction did not preclude the regulation of TCR signaling by these proteins.
Materias Unesco
24 Ciencias de la Vida
Palabras Clave
Autoinmunidad
Proteína tirosina fosfatasa
ISSN
1932-6203
Revisión por pares
SI
Patrocinador
Ministerio de Ciencia e Innovación (grant SAF2009-09724)
Version del Editor
Propietario de los Derechos
© Public Library of Science
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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