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dc.contributor.authorGonzález Obeso, Constancio
dc.contributor.authorGonzález Pérez, Miguel 
dc.contributor.authorMano, João
dc.contributor.authorAlonso Rodrigo, Matilde 
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.date.accessioned2021-08-11T13:52:19Z
dc.date.available2021-08-11T13:52:19Z
dc.date.issued2020
dc.identifier.citationSmall 2020, 16, 2005191es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/47854
dc.descriptionProducción Científicaes
dc.description.abstractThe development of intricate and complex self-assembling structures in the micrometer range, such as biomorphs, is a major challenge in materials science. Although complex structures can be obtained from self-assembling materials as they segregate from solution, their size is usually in the nanometer range or requires accessory techniques. Previous studies with intrinsically disordered proteins (IDPs) have shown that the active interplay of different molecular interactions provides access to new and more complex nanostructures. As such, it is hypothesized that enriching the variety of intra- and intermolecular interactions in a model IDP will widen the landscape of sophisticated intermediate structures that can be accessed. In this study, a model silk-elastin-like recombinamer capable of interacting via three non-covalent interactions, namely hydrophobic, ion-pairing, and H-bonding is built. This model material is shown to self-assemble into complex stable micrometer-sized biomorphs. Variation of the block composition, pH, and temperature demonstrates the necessary intees
dc.format.mimetypeapplication/pdfes
dc.language.isospaes
dc.publisherAdvanced Science Newses
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.titleComplex morphogenesis by a model intrinsically disordered proteines
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1002/smll.202005191.es
dc.relation.publisherversionwww.small-journal.comes
dc.identifier.publicationfirstpage1es
dc.identifier.publicationissue10es
dc.identifier.publicationlastpage10es
dc.identifier.publicationtitleSmalles
dc.identifier.publicationvolume16es
dc.peerreviewedSIes
dc.description.projectThe authors are grateful for the funding from the Spanish Government (MAT2016-78903-R, RTI2018-096320-B-C22, FPU15-00448, PID2019- 110709RB-100), Junta de Castilla y León (VA317P18), Interreg V España Portugal POCTEP (0624_2IQBIONEURO_6_E) and Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Leónes
dc.type.hasVersioninfo:eu-repo/semantics/submittedVersiones


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