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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/51149

    Título
    Glutathione determination and a study of the activity of glutathione-peroxidase, glutathione-transferase, and glutathione-reductase in renal transplants
    Autor
    Vega, L. de
    Pérez Fernández, RebecaAutoridad UVA Orcid
    Martin Mateo, María Concepción
    Bustamante Bustamante, JesúsAutoridad UVA
    Mendiluce Herrero, AliciaAutoridad UVA
    Bustamante Munguira, ElenaAutoridad UVA Orcid
    Año del Documento
    2002
    Editorial
    Taylor & Francis
    Descripción
    Producción Científica
    Documento Fuente
    Renal Failure, 2002, vol. 24, n. 4, p. 421–432
    Resumen
    The aim of this work is to study the temporary variation of oxidative stress in renal transplants, both in plasma andin erythrocytes (CR). In order to do so, we determined total glutathione (GST) levels, both oxidized (GSSG) and reduced (GSH), and the activity of enzymes, glutathione peroxidase (G-px), glutathione reductase (G-red) and glutathione transferase (GSt), in renal transplant patients. Determinations were made 48 h before the transplant 1 week and 2 weeks after the renal transplant. The results obtainedconfirm a high ‘‘oxidative stress’’ rate, resulting from the equilibrium between the production of free radicals andthe activity of antioxidants, the former being higher proportionally. Immediately after the transplant there is an increase of oxidative stress, which results in an increase of G-red, a marked decrease of G-px in plasma andin erythrocytes (CR) andan abrupt drop both in GST levels in plasma andin GSG (as well as in the [GSH]/[GSSG] relationship). As times goes on, after the transplant, there is a significant improvement in the activity of antioxidant enzymes, but there is no normalization, which is easily seen in the fact that total glutathione levels andthe activity of the various enzymes approach the average values of the control group.
    Materias (normalizadas)
    Riñones - Trasplante
    Riñones - Enfermedades
    Enzimas
    Materias Unesco
    3205.06 Nefrología
    ISSN
    0886-022X
    Revisión por pares
    SI
    DOI
    10.1081/JDI-120006769
    Version del Editor
    https://www.tandfonline.com/doi/full/10.1081/JDI-120006769
    Propietario de los Derechos
    © 2002 Taylor & Francis
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/51149
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP52 - Artículos de revista [181]
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    Universidad de Valladolid

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