Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/51372
Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
Año del Documento
MICROCHEMICAL JOURNAL, 175 (2022) 107148
This paper presents a comparison of three different analytical proposals for the determination of 60 pharmaceuticals and personal care products (PPCPs) in solid urban sewage sludge. Two fast sample pretreatments, i.e., online solid-phase-extraction (online SPE) and direct injection (DI), were tested against the conventional offline solid phase extraction (offline SPE). In all cases, subsequently, extracts underwent ultra-high-performance-liquid chromatography coupled to tandem-mass-spectrometry (UHPLC-MS/MS), simultaneously operating in both positive and negative electrospray ionization (ESI) mode. In addition, as solid matrices, clean-up steps were necessarily preceded by ultra-sound-assisted extraction (UAE) in all cases. Matrix-matched quantification was combined with internal standard providing high reliability to all three approaches. Best performance was observed for the fully automatized and non-pretreated DI method, showing limits of detection below 30 ng g-1 for many of the target compounds, and recoveries between 80 and 120%. Finally, the best working method was validated and applied to the analysis of PPCPs in different dewatered digested sludge samples from the wastewater treatment plant (WWTP) in Valladolid (Spain). Acetaminophen was found at concentrations above 1,000 ng g-1.
Compounds of emerging concern (CECs)
Revisión por pares
This work was supported by the University of Valladolid (UVa) through its General Foundation (063/136391), by the Spanish Government (MINECO-CTM2015-70722-R) and by the Regional Government of Castilla y León and the EU-FEDER (CLU 2017–09, UIC 071, INFRARED2018-UVA3, and VA080G18). It was partially carried out in the Laboratory of Instrumental Techniques from the UVa. The UVa is also recognized for the postdoctoral contract held by Rebeca López Serna (2018POSTDOC UVA12).
Propietario de los Derechos
Tipo de versión