Mostrar el registro sencillo del ítem

dc.contributor.authorÁlvarez Martín, Javier 
dc.contributor.authorÁlvarez Illera, María Pilar
dc.contributor.authorGarcía Casas, Paloma 
dc.contributor.authorFonteriz García, Rosalba Inés 
dc.contributor.authorMontero Zoccola, María Teresa 
dc.date.accessioned2022-03-24T09:30:28Z
dc.date.available2022-03-24T09:30:28Z
dc.date.issued2020
dc.identifier.citationCells, 2020, vol. 9, n. 1, 204es
dc.identifier.issn2073-4409es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/52623
dc.descriptionProducción Científicaes
dc.description.abstractCa2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation. There is ample evidence that the dysregulation of Ca2+ signaling is one of the key events in the development of neurodegenerative processes, an idea called the “calcium hypothesis” of neurodegeneration. Caenorhabditis elegans (C. elegans) is a very good model for the study of aging and neurodegeneration. In fact, many of the signaling pathways involved in longevity were first discovered in this nematode, and many models of neurodegenerative diseases have also been developed therein, either through mutations in the worm genome or by expressing human proteins involved in neurodegeneration (β-amyloid, α-synuclein, polyglutamine, or others) in defined worm tissues. The worm is completely transparent throughout its whole life, which makes it possible to carry out Ca2+ dynamics studies in vivo at any time, by expressing Ca2+ fluorescent probes in defined worm tissues, and even in specific organelles such as mitochondria. This review will summarize the evidence obtained using this model organism to understand the role of Ca2+ signaling in aging and neurodegeneration.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.classificationCalciumes
dc.subject.classificationCalcioes
dc.subject.classificationCaenorhabditis eleganses
dc.subject.classificationNeurodegenerationes
dc.subject.classificationNeurodegeneraciónes
dc.titleThe role of Ca2+ signaling in aging and neurodegeneration: Insights from caenorhabditis elegans modelses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2020 The Authorses
dc.identifier.doi10.3390/cells9010204es
dc.relation.publisherversionhttps://www.mdpi.com/2073-4409/9/1/204es
dc.peerreviewedSIes
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem