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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/52623

    Título
    The role of Ca2+ signaling in aging and neurodegeneration: Insights from caenorhabditis elegans models
    Autor
    Álvarez Martín, JavierAutoridad UVA Orcid
    Álvarez Illera, María Pilar
    García Casas, PalomaAutoridad UVA
    Fonteriz García, Rosalba InésAutoridad UVA Orcid
    Montero Zoccola, María TeresaAutoridad UVA Orcid
    Año del Documento
    2020
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Cells, 2020, vol. 9, n. 1, 204
    Abstract
    Ca2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation. There is ample evidence that the dysregulation of Ca2+ signaling is one of the key events in the development of neurodegenerative processes, an idea called the “calcium hypothesis” of neurodegeneration. Caenorhabditis elegans (C. elegans) is a very good model for the study of aging and neurodegeneration. In fact, many of the signaling pathways involved in longevity were first discovered in this nematode, and many models of neurodegenerative diseases have also been developed therein, either through mutations in the worm genome or by expressing human proteins involved in neurodegeneration (β-amyloid, α-synuclein, polyglutamine, or others) in defined worm tissues. The worm is completely transparent throughout its whole life, which makes it possible to carry out Ca2+ dynamics studies in vivo at any time, by expressing Ca2+ fluorescent probes in defined worm tissues, and even in specific organelles such as mitochondria. This review will summarize the evidence obtained using this model organism to understand the role of Ca2+ signaling in aging and neurodegeneration.
    Materias Unesco
    2415 Biología Molecular
    Palabras Clave
    Calcio
    Neurodegeneración
    Ca2+
    C. elegans
    neurodegeneration
    Alzheimer
    Parkinson
    SERCA
    IP3 receptor
    ryanodine receptor
    ISSN
    2073-4409
    Revisión por pares
    SI
    DOI
    10.3390/cells9010204
    Patrocinador
    MICINN project BFU2017-83509-R
    Junta de Castilla y León project VA011G18
    Version del Editor
    https://www.mdpi.com/2073-4409/9/1/204
    Propietario de los Derechos
    © 2020 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/52623
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IBGM - Artículos de revista [78]
    • DEP06 - Artículos de revista [352]
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    Universidad de Valladolid

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