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dc.contributor.authorWu, Yuanhao
dc.contributor.authorFortunato, Gabriele Maria
dc.contributor.authorOkesola, Babatunde O
dc.contributor.authorPellerej Di Brocchetti, Francesco Luigi
dc.contributor.authorSuntornnond, Ratima
dc.contributor.authorConnelly, John
dc.contributor.authorDe Maria, Carmelo
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorVozzi, Giovanni
dc.contributor.authorWang, Wen
dc.contributor.authorMata, Álvaro
dc.date.accessioned2022-07-12T08:11:38Z
dc.date.available2022-07-12T08:11:38Z
dc.date.issued2021
dc.identifier.citationBiofabrication, 2021, vol.13, n. 3, p. 035027es
dc.identifier.issn1758-5082es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/53898
dc.descriptionProducción Científicaes
dc.description.abstractSelf-assembling bioinks offer the possibility to biofabricate with molecular precision, hierarchical control, and biofunctionality. For this to become a reality with widespread impact, it is essential to engineer these ink systems ensuring reproducibility and providing suitable standardization. We have reported a self-assembling bioink based on disorder-to-order transitions of an elastin-like recombinamer (ELR) to co-assemble with graphene oxide (GO). Here, we establish reproducible processes, optimize printing parameters for its use as a bioink, describe new advantages that the self-assembling bioink can provide, and demonstrate how to fabricate novel structures with physiological relevance. We fabricate capillary-like structures with resolutions down to ∼10 µm in diameter and ∼2 µm thick tube walls and use both experimental and finite element analysis to characterize the printing conditions, underlying interfacial diffusion-reaction mechanism of assembly, printing fidelity, and material porosity and permeability. We demonstrate the capacity to modulate the pore size and tune the permeability of the resulting structures with and without human umbilical vascular endothelial cells. Finally, the potential of the ELR-GO bioink to enable supramolecular fabrication of biomimetic structures was demonstrated by printing tubes exhibiting walls with progressively different structure and permeability.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherIOP Publishinges
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.classificationBioinkes
dc.subject.classificationBiotintaes
dc.subject.classificationSelf-assemblinges
dc.subject.classificationAutoensamblajees
dc.subject.classificationAnisotropices
dc.subject.classificationAnisótropoes
dc.titleAn interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeabilityes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2021 The Author(s)es
dc.rights.holder© Copyright 2021 IOP Publishinges
dc.identifier.doi10.1088/1758-5090/abe4c3es
dc.relation.publisherversionhttps://iopscience.iop.org/article/10.1088/1758-5090/abe4c3es
dc.identifier.publicationfirstpage035027es
dc.identifier.publicationissue3es
dc.identifier.publicationtitleBiofabricationes
dc.identifier.publicationvolume13es
dc.peerreviewedSIes
dc.description.projectThe work was supported by the ERC Starting Grant (STROFUNSCAFF), the Medical Research Council (UK Regenerative Medicine Platform Acellular/Smart Materials 3D Architecture, MR/R015651/1), and the AO Foundation AOCMF-17-19M.es
dc.identifier.essn1758-5090es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco22 Físicaes


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