dc.contributor.author | Wu, Yuanhao | |
dc.contributor.author | Fortunato, Gabriele Maria | |
dc.contributor.author | Okesola, Babatunde O | |
dc.contributor.author | Pellerej Di Brocchetti, Francesco Luigi | |
dc.contributor.author | Suntornnond, Ratima | |
dc.contributor.author | Connelly, John | |
dc.contributor.author | De Maria, Carmelo | |
dc.contributor.author | Rodríguez Cabello, José Carlos | |
dc.contributor.author | Vozzi, Giovanni | |
dc.contributor.author | Wang, Wen | |
dc.contributor.author | Mata, Álvaro | |
dc.date.accessioned | 2022-07-12T08:11:38Z | |
dc.date.available | 2022-07-12T08:11:38Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Biofabrication, 2021, vol.13, n. 3, p. 035027 | es |
dc.identifier.issn | 1758-5082 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/53898 | |
dc.description | Producción Científica | es |
dc.description.abstract | Self-assembling bioinks offer the possibility to biofabricate with molecular precision, hierarchical control, and biofunctionality. For this to become a reality with widespread impact, it is essential to engineer these ink systems ensuring reproducibility and providing suitable standardization. We have reported a self-assembling bioink based on disorder-to-order transitions of an elastin-like recombinamer (ELR) to co-assemble with graphene oxide (GO). Here, we establish reproducible processes, optimize printing parameters for its use as a bioink, describe new advantages that the self-assembling bioink can provide, and demonstrate how to fabricate novel structures with physiological relevance. We fabricate capillary-like structures with resolutions down to ∼10 µm in diameter and ∼2 µm thick tube walls and use both experimental and finite element analysis to characterize the printing conditions, underlying interfacial diffusion-reaction mechanism of assembly, printing fidelity, and material porosity and permeability. We demonstrate the capacity to modulate the pore size and tune the permeability of the resulting structures with and without human umbilical vascular endothelial cells. Finally, the potential of the ELR-GO bioink to enable supramolecular fabrication of biomimetic structures was demonstrated by printing tubes exhibiting walls with progressively different structure and permeability. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | IOP Publishing | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.classification | Bioink | es |
dc.subject.classification | Biotinta | es |
dc.subject.classification | Self-assembling | es |
dc.subject.classification | Autoensamblaje | es |
dc.subject.classification | Anisotropic | es |
dc.subject.classification | Anisótropo | es |
dc.title | An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2021 The Author(s) | es |
dc.rights.holder | © Copyright 2021 IOP Publishing | es |
dc.identifier.doi | 10.1088/1758-5090/abe4c3 | es |
dc.relation.publisherversion | https://iopscience.iop.org/article/10.1088/1758-5090/abe4c3 | es |
dc.identifier.publicationfirstpage | 035027 | es |
dc.identifier.publicationissue | 3 | es |
dc.identifier.publicationtitle | Biofabrication | es |
dc.identifier.publicationvolume | 13 | es |
dc.peerreviewed | SI | es |
dc.description.project | The work was supported by the ERC Starting Grant (STROFUNSCAFF), the Medical Research Council (UK Regenerative Medicine Platform Acellular/Smart Materials 3D Architecture, MR/R015651/1), and the AO Foundation AOCMF-17-19M. | es |
dc.identifier.essn | 1758-5090 | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
dc.subject.unesco | 22 Física | es |
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