• español
  • English
  • français
  • Deutsch
  • português (Brasil)
  • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Navegar

    Todo o repositórioComunidadesPor data do documentoAutoresAssuntosTítulos

    Minha conta

    Entrar

    Estatística

    Ver as estatísticas de uso

    Compartir

    Ver item 
    •   Página inicial
    • PRODUÇÃO CIENTÍFICA
    • Departamentos
    • Dpto. Anatomia y Radiología
    • DEP04 - Artículos de revista
    • Ver item
    •   Página inicial
    • PRODUÇÃO CIENTÍFICA
    • Departamentos
    • Dpto. Anatomia y Radiología
    • DEP04 - Artículos de revista
    • Ver item
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano

    Exportar

    RISMendeleyRefworksZotero
    • edm
    • marc
    • xoai
    • qdc
    • ore
    • ese
    • dim
    • uketd_dc
    • oai_dc
    • etdms
    • rdf
    • mods
    • mets
    • didl
    • premis

    Citas

    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/5540

    Título
    Prenatal expression of interleukin 1B and interleukin 6 in the rat pituitary gland
    Autor
    Moro Balbás, José AntonioAutoridad UVA Orcid
    Carretero, José
    Alonso Revuelta, María IsabelAutoridad UVA Orcid
    Martín, C.
    Gato Casado, Ángel LuisAutoridad UVA Orcid
    Mano Bonín, Anibal de laAutoridad UVA
    Año del Documento
    2008
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Citokine, XXX, 2008
    Resumo
    It is known that interleukin 1b (IL-1b) and interleukin 6 (IL-6) are expressed post-natally in normal and tumoral cells in the anterior pituitary, and that they play a role in both the liberation of different hormones and in the growth, proliferation and tumor formation of the pituitary gland. However, their expression and role during embryonic and fetal development remain unknown. We have performed an immunocytochemistry study of prenatal expression and distribution of IL-1b and IL-6 in isolated embryonic rat Rathke’s pouch prior to birth, more specifically between 13.5 and 19.5 days p.c. Western-blot analysis carried out on 19.5-day p.c. embryos showed positive immunolabelling for IL-1b and IL-6. These interleukins were initially expressed simultaneously in the rostral and ventral portions of Rathke’s pouch in 15.5-day p.c. embryos, and this expression progressed caudodorsally in later developmental stages, extending to most of the hypophysis before birth. The number of cells expressing these interleukins increased throughout this period: 48.22% of anterior pituitary cells expressed IL-6 in 19.5-day embryos, whilst IL-1b was positive in 39.8% of the cells. Moreover, we have demonstrated that some adenohypophyseal cells co-express both interleukins. Such findings represent the first step towards an understanding of the physiological role of these interleukins in anterior pituitary development.
    Materias (normalizadas)
    Citoquímica
    Hipófisis - Cáncer
    Revisión por pares
    SI
    DOI
    10.1016/j.cyto.2008.08.005
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S1043466608006881
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/5540
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP04 - Artículos de revista [57]
    Mostrar registro completo
    Arquivos deste item
    Nombre:
    Gato22.pdf
    Tamaño:
    809.6Kb
    Formato:
    Adobe PDF
    Descripción:
    PD-73
    Thumbnail
    Visualizar/Abrir
    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExceto quando indicado o contrário, a licença deste item é descrito como Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

    Powered by MIT's. DSpace software, Version 5.10