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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/57049

    Título
    Structural brain changes in patients with persistent headache after COVID-19 resolution
    Autor
    Planchuelo Gómez, ÁlvaroAutoridad UVA Orcid
    García Azorín, DavidAutoridad UVA Orcid
    Guerrero Peral, Angel LuisAutoridad UVA Orcid
    Rodríguez, Margarita
    Aja Fernández, SantiagoAutoridad UVA Orcid
    Luis García, Rodrigo deAutoridad UVA Orcid
    Año del Documento
    2022
    Editorial
    Springer
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Neurology, 2022.
    Zusammenfassung
    Headache is among the most frequently reported symptoms after resolution of COVID-19. We assessed structural brain changes using T1- and diffusion-weighted MRI processed data from 167 subjects: 40 patients who recovered from COVID- 19 but suffered from persistent headache without prior history of headache (COV), 41 healthy controls, 43 patients with episodic migraine and 43 patients with chronic migraine. To evaluate gray matter and white matter changes, morphometry parameters and diffusion tensor imaging-based measures were employed, respectively. COV patients showed significant lower cortical gray matter volume and cortical thickness than healthy subjects (p < 0.05, false discovery rate corrected) in the inferior frontal and the fusiform cortex. Lower fractional anisotropy and higher radial diffusivity (p < 0.05, family-wise error corrected) were observed in COV patients compared to controls, mainly in the corpus callosum and left hemisphere. COV patients showed higher cortical volume and thickness than migraine patients in the cingulate and frontal gyri, paracentral lobule and superior temporal sulcus, lower volume in subcortical regions and lower curvature in the precuneus and cuneus. Lower diffusion metric values in COV patients compared to migraine were identified prominently in the right hemisphere. COV patients present diverse changes in the white matter and gray matter structure. White matter changes seem to be associ- ated with impairment of fiber bundles. Besides, the gray matter changes and other white matter modifications such as axonal integrity loss seemed subtle and less pronounced than those detected in migraine, showing that persistent headache after COVID-19 resolution could be an intermediate state between normality and migraine.
    Materias Unesco
    32 Ciencias Médicas
    Palabras Clave
    COVID-19
    Headache
    Gray matter
    Diffusion tensor imaging
    Migraine
    ISSN
    0340-5354
    Revisión por pares
    SI
    DOI
    10.1007/s00415-022-11398-z
    Patrocinador
    Gerencia Regional de Salud (GRS) de Castilla y León, (GRS 2284/A/2020)
    Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE
    Version del Editor
    https://link.springer.com/article/10.1007/s00415-022-11398-z
    Propietario de los Derechos
    © 2022 The Author(s)
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/57049
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • LPI - Artículos de Revista [9]
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    Dateien zu dieser Ressource
    Nombre:
    Structural-brain-changes-patients.pdf
    Tamaño:
    4.232Mb
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    Universidad de Valladolid

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