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Título
Structural brain changes in patients with persistent headache after COVID-19 resolution
Autor
Año del Documento
2022
Editorial
Springer
Descripción
Producción Científica
Documento Fuente
Journal of Neurology, 2022.
Resumen
Headache is among the most frequently reported symptoms after resolution of COVID-19. We assessed structural brain
changes using T1- and diffusion-weighted MRI processed data from 167 subjects: 40 patients who recovered from COVID-
19 but suffered from persistent headache without prior history of headache (COV), 41 healthy controls, 43 patients with
episodic migraine and 43 patients with chronic migraine. To evaluate gray matter and white matter changes, morphometry
parameters and diffusion tensor imaging-based measures were employed, respectively. COV patients showed significant
lower cortical gray matter volume and cortical thickness than healthy subjects (p < 0.05, false discovery rate corrected) in the
inferior frontal and the fusiform cortex. Lower fractional anisotropy and higher radial diffusivity (p < 0.05, family-wise error
corrected) were observed in COV patients compared to controls, mainly in the corpus callosum and left hemisphere. COV
patients showed higher cortical volume and thickness than migraine patients in the cingulate and frontal gyri, paracentral
lobule and superior temporal sulcus, lower volume in subcortical regions and lower curvature in the precuneus and cuneus.
Lower diffusion metric values in COV patients compared to migraine were identified prominently in the right hemisphere.
COV patients present diverse changes in the white matter and gray matter structure. White matter changes seem to be associ-
ated with impairment of fiber bundles. Besides, the gray matter changes and other white matter modifications such as axonal
integrity loss seemed subtle and less pronounced than those detected in migraine, showing that persistent headache after
COVID-19 resolution could be an intermediate state between normality and migraine.
Materias Unesco
32 Ciencias Médicas
Palabras Clave
COVID-19
Headache
Gray matter
Diffusion tensor imaging
Migraine
ISSN
0340-5354
Revisión por pares
SI
Patrocinador
Gerencia Regional de Salud (GRS) de Castilla y León, (GRS 2284/A/2020)
Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE
Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE
Version del Editor
Propietario de los Derechos
© 2022 The Author(s)
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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