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dc.contributor.authorFernández Lázaro, Diego 
dc.contributor.authorMielgo Ayuso, Juan Francisco 
dc.contributor.authorCórdova Martínez, Alfredo 
dc.contributor.authorSeco Calvo, Jesús
dc.date.accessioned2023-03-27T08:24:48Z
dc.date.available2023-03-27T08:24:48Z
dc.date.issued2020
dc.identifier.citationNutrients, 2020, vol.12, n. 6, 1886es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/59014
dc.descriptionProducción Científicaes
dc.description.abstractBlack pepper (Piper nigrum L.) has been employed in medicine (epilepsy, headaches, and diabetes), where its effects are mainly attributed to a nitrogen alkaloid called piperidine (1-(1-[1,3-benzodioxol-5-yl]-1-oxo-2,4 pentenyl) piperidine). Piperine co-administered with vitamins and minerals has improved its absorption. Therefore, this study aimed to describe the impact of the joint administration of iron (Fe) plus black pepper in physically active healthy individuals. Fe is a micronutrient that aids athletic performance by influencing the physiological functions involved in endurance sports by improving the transport, storage, and utilization of oxygen. Consequently, athletes have risk factors for Fe depletion, Fe deficiency, and eventually, anemia, mainly from mechanical hemolysis, gastrointestinal disturbances, and loss of Fe through excessive sweating. Declines in Fe stores have been reported to negatively alter physical capacities such as aerobic capacity, strength, and skeletal muscle recovery in elite athletes. Thus, there is a need to maintain Fe storage, even if Fe intake meets the recommended daily allowance (RDA), and Fe supplementation may be justified in physically active individuals, in states of Fe deficiency, with or without anemia. Females, in particular, should monitor their Fe hematological profile. The recommended oral Fe supplements are ferrous or ferric salts, sulfate, fumarate, and gluconate. These preparations constitute the first line of treatment; however, the high doses administered have gastrointestinal side effects that reduce tolerance and adherence to treatment. Thus, a strategy to counteract these adverse effects is to improve the bioavailability of Fe. Therefore, piperine may benefit the absorption of Fe through its bioavailability enhancement properties. Three research studies of Fe associated with black pepper have reported improvements in parameters related to the metabolism of Fe, without adverse effects. Although more research is needed, this could represent an advance in oral Fe supplementation for physically active individuals.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectFisiologíaes
dc.subjectMedicina deportivaes
dc.subjectFarmacologíaes
dc.subject.classificationPiperinees
dc.subject.classificationIrones
dc.subject.classificationSupplementationes
dc.subject.classificationPhysical activityes
dc.subject.classificationPiperinaes
dc.subject.classificationHierroes
dc.subject.classificationSuplementaciónes
dc.subject.classificationActividad físicaes
dc.titleIron and physical activity: Bioavailability enhancers, properties of black pepper (Bioperine®) and potential applicationses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2020 The Authorses
dc.identifier.doi10.3390/nu12061886es
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/12/6/1886es
dc.identifier.publicationfirstpage1886es
dc.identifier.publicationissue6es
dc.identifier.publicationtitleNutrientses
dc.identifier.publicationvolume12es
dc.peerreviewedSIes
dc.identifier.essn2072-6643es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco3209 Farmacologíaes
dc.subject.unesco2411 Fisiología Humanaes


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