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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/61355

    Título
    Spherical means-based free-water volume fraction from diffusion MRI increases non-linearly with age in the white matter of the healthy human brain
    Autor
    Pieciak, TomászAutoridad UVA
    París Brandés, Guillem Lluis
    Beck, Dani
    Maximov, Ivan I.
    Tristán Vega, AntonioAutoridad UVA Orcid
    Luis García, Rodrigo deAutoridad UVA Orcid
    Westlye, Lars T.
    Aja Fernández, SantiagoAutoridad UVA Orcid
    Año del Documento
    2023
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    NeuroImage, 2023, vol. 279, 120324
    Résumé
    The term free-water volume fraction (FWVF) refers to the signal fraction that could be found as the cerebrospinal fluid of the brain, which has been demonstrated as a sensitive measure that correlates with cognitive performance and various neuropathological processes. It can be quantified by properly fitting the isotropic component of the magnetic resonance (MR) signal in diffusion-sensitized sequences. Using healthy subjects (178F/109M) aged 25-94, this study examines in detail the evolution of the FWVF obtained with the spherical means technique from multi-shell acquisitions in the human brain white matter across the adult lifespan, which has been previously reported to exhibit a positive trend when estimated from single-shell data using the bi-tensor signal representation. We found evidence of a noticeably non-linear gain after the sixth decade of life, with a region-specific variate and varying change rate of the spherical means-based multi-shell FWVF parameter with age, at the same time, a heteroskedastic pattern across the adult lifespan is suggested. On the other hand, the FW corrected diffusion tensor imaging (DTI) leads to a region-dependent flattened age-related evolution of the mean diffusivity (MD) and fractional anisotropy (FA), along with a considerable reduction in their variability, as compared to the studies conducted over the standard (single-component) DTI. This way, our study provides a new perspective on the trajectory-based assessment of the brain and explains the conceivable reason for the variations observed in FA and MD parameters across the lifespan with previous studies under the standard diffusion tensor imaging.
    Materias (normalizadas)
    Neurosciences
    Cerebro
    Resonancia magnética
    Materias Unesco
    2211.18 Resonancia Magnética
    2490.01 Neurofisiología
    Palabras Clave
    Brain
    White matter
    Aging
    Cerebro
    Materia blanca
    Envejecimiento
    ISSN
    1053-8119
    Revisión por pares
    SI
    DOI
    10.1016/j.neuroimage.2023.120324
    Patrocinador
    Ministerio de Ciencia e Innovación (MCIN-AEI) y FEDER-UE (grant PID2021-124407NB-I00)
    Ministerio de Ciencia e Innovación (MCIN-AEI) - Unión Europea “NextGenerationEU/PRTR” (grant TED2021-130758B-I00)
    Ministry of Science and Higher Education (Poland) - Bekker programme (grant PPN/BEK/2019/1/00421)
    Norwegian ExtraFoundation for Health and Rehabilitation (2015/FO5146)
    European Union's Horizon 2020 research and Innovation program (ERC 802998)
    Patrocinador
    info:eu-repo/grantAgreement/EC/H2020/802998
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S1053811923004755?via%3Dihub
    Propietario de los Derechos
    © 2023 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/61355
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • LPI - Artículos de Revista [9]
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    Spherical-means-based-free-water.pdf
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    Attribution-NonCommercial-NoDerivatives 4.0 InternacionalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 Internacional

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