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dc.contributor.authorLuis Román, Daniel Antonio de 
dc.contributor.authorPrimo Martín, David
dc.contributor.authorIzaola Jauregui, Olatz
dc.contributor.authorAller de la Fuente, Rocío 
dc.date.accessioned2023-09-29T11:31:29Z
dc.date.available2023-09-29T11:31:29Z
dc.date.issued2022
dc.identifier.citationNutrients, 2022, Vol. 14, Nº. 12, 2427es
dc.identifier.issn2072-6643es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/61852
dc.descriptionProducción Científicaes
dc.description.abstractIn cross-sectional studies, the genetic variant rs662799 of the APOA5 gene is associated with high serum triglyceride concentrations, and in some studies, the effect of short-term dietary interventions has been evaluated. The aim of the present investigation was to evaluate the role of this genetic variant in metabolic changes after the consumption of a low-calorie diet with a Mediterranean pattern for 9 months. A population of 269 Caucasian obese patients was recruited. Adiposity and biochemical parameters were measured at the beginning (basal level) and after 3 and 9 months of the dietary intervention. The rs662799 genotype was assessed with a dominant analysis (TT vs. CT + CC). The APOA5 variant distribution was: 88.1% (n = 237) (TT), 11.5% (n = 31) (TC) and 0.4% (n = 1) (CC). There were significant differences only in triglyceride levels at all times of the study between the genotype groups. After 3 and 9 months of dietary intervention, the following parameters improved in both genotype groups: adiposity parameters, systolic pressure, total cholesterol, LDL cholesterol, leptin, adiponectin and the leptin/adiponectin ratio. The intervention significantly decreased insulin levels, HOMA-IR and triglyceride levels in non-C allele carriers (Delta 9 months TT vs. TC + CC). i.e., insulin levels (delta: −3.8 + 0.3 UI/L vs. −1.2 + 0.2 UI/L; p = 0.02), HOMA-IR levels (delta: −1.2 + 0.2 units vs. −0.3 + 0.1 units; p = 0.02), triglyceride levels (delta: −19.3 + 4.2 mg/dL vs. −4.2 + 3.0 mg/dL; p = 0.02). In conclusion, non-C allele carriers of rs662799 of the APOA5 gene showed a decrease of triglyceride, insulin and HOMA-IR levels after consuming a low-calorie diet with a Mediterranean pattern; we did not observe this effect in C allele carriers, despite a significant weight loss.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHuman geneticses
dc.subjectGenética humanaes
dc.subjectRegímenes alimentarioses
dc.subjectNutritiones
dc.subjectNutriciónes
dc.subjectDieteticses
dc.subjectDietéticaes
dc.subjectDiet therapyes
dc.subjectDietes
dc.subjectDietaes
dc.subjectFood Sciencees
dc.subjectTriglycerideses
dc.subjectTriglicéridoses
dc.titleAssociation of the APOA-5 genetic variant rs662799 with metabolic changes after an intervention for 9 months with a low-calorie diet with a Mediterranean profilees
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2022 The Authorses
dc.identifier.doi10.3390/nu14122427es
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/14/12/2427es
dc.identifier.publicationfirstpage2427es
dc.identifier.publicationissue12es
dc.identifier.publicationtitleNutrientses
dc.identifier.publicationvolume14es
dc.peerreviewedSIes
dc.identifier.essn2072-6643es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco3206 Ciencias de la Nutriciónes
dc.subject.unesco32 Ciencias Médicases


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