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dc.contributor.author | Fernández Peña, Laura | |
dc.contributor.author | López Hernández, Enol | |
dc.contributor.author | Sánchez González, Ángel | |
dc.contributor.author | Barbero Pérez, María Asunción | |
dc.date.accessioned | 2023-12-22T12:17:07Z | |
dc.date.available | 2023-12-22T12:17:07Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Molecules, 2023, Vol. 28, Nº. 7, 3080 | es |
dc.identifier.issn | 1420-3049 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/63811 | |
dc.description | Producción Científica | es |
dc.description.abstract | A convenient regioselective synthesis of allyl- and vinylsilyl alcohols, from a common precursor, was described, by selecting the appropriate reaction conditions. Allyl- and vinylsilyl alcohols were tested in silyl-Prins cyclizations for the preparation of disubstituted oxygenated heterocycles in a one-pot sequential reaction. The methodology was sensitive to the structure of the starting alkenylsilyl alcohol and reaction conditions, with competitive pathways observed (particularly for allylsilyl alcohols), such as Peterson elimination and oxonia-Cope reactions. However, the use of vinylsilyl alcohols allowed the preparation of differently disubstituted cis-2,6-dihydropyrans in moderate to good yields. Computational studies support the proposed mechanism. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Heterocyclic compounds | es |
dc.subject | Compuestos heterocíclicos | es |
dc.subject | Analytical chemistry | es |
dc.subject.classification | Prins cyclization | es |
dc.subject.classification | Oxacycles | es |
dc.title | Diastereoselective synthesis of cis-2,6-disubstituted dihydropyrane derivatives through a competitive silyl-prins cyclization versus alternative reaction pathways | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2023 The authors | es |
dc.identifier.doi | 10.3390/molecules28073080 | es |
dc.relation.publisherversion | https://www.mdpi.com/1420-3049/28/7/3080 | es |
dc.identifier.publicationfirstpage | 3080 | es |
dc.identifier.publicationissue | 7 | es |
dc.identifier.publicationtitle | Molecules | es |
dc.identifier.publicationvolume | 28 | es |
dc.peerreviewed | SI | es |
dc.description.project | Junta de Castilla y León - (grant VA294-P18) | es |
dc.description.project | Ministerio de Ciencia e Innovación - (PID2020-116076RJI00/AEI/10.13039/501100011033) | es |
dc.identifier.essn | 1420-3049 | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
dc.subject.unesco | 2301 Química Analítica | es |
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