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dc.contributor.authorMartín Fernández, Marta 
dc.contributor.authorAller de la Fuente, Rocío 
dc.contributor.authorHeredia Rodríguez, María 
dc.contributor.authorGómez Sánchez, Esther 
dc.contributor.authorMartínez de Paz, Pedro José 
dc.contributor.authorGonzalo Benito, Hugo 
dc.contributor.authorSánchez de Prada, Laura
dc.contributor.authorGorgojo Galindo, Óscar 
dc.contributor.authorCarnicero Frutos, Irene
dc.contributor.authorTamayo Gómez, Eduardo 
dc.contributor.authorTamayo Velasco, Álvaro 
dc.date.accessioned2024-01-15T14:28:31Z
dc.date.available2024-01-15T14:28:31Z
dc.date.issued2021
dc.identifier.citationRedox Biol. 2021 Nov 6;48:102181es
dc.identifier.issn2213-2317es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/64526
dc.description.abstractBackground: Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in response to infections. A defective redox balance has been related to viral pathogenesis developing a massive induction of cell death provoked by oxidative stress. The aim of this study is to perform a complete oxidative stress profile evaluation regarding antioxidant enzymes, total antioxidant capacity and oxidative cell damage in order to characterize its role in diagnosis and severity of this disease. Methods: Blood samples were obtained from 108 COVID-19 patients and 28 controls and metabolites representative of oxidative stress were assessed. The association between lipid peroxidation and 28-day intubation/death risk was evaluated by multivariable regression analysis. Probability of intubation/death to day-28 was analyzed by using Kaplan-Meier curves and tested with the log-rank test. Results: Antioxidant enzymes (Superoxide dismutase (SOD) and Catalase) and oxidative cell damage (Carbonyl and Lipid peroxidation (LPO)) levels were significantly higher in COVID-19 patients while total antioxidant capacity (ABTS and FRAP) levels were lower in these patients. The comparison of oxidative stress molecules’ levels across COVID-19 severity revealed that only LPO was statistically different between mild and intubated/ death COVID-19 patients. COX multivariate regression analysis identified LPO levels over the OOP (LPO>1948.17 μM) as an independent risk factor for 28-day intubation/death in COVID-19 patients [OR: 2.57; 95% CI: 1.10–5.99; p = 0.029]. Furthermore, Kaplan-Meier curve analysis revealed that COVID-19 patients showing LPO levels above 1948.17 μM were intubated or died 8.4 days earlier on average (mean survival time 15.4 vs 23.8 days) when assessing 28-day intubation/death risk (p < 0.001). Conclusion: These findings deepen our knowledge of oxidative stress status in SARS-CoV-2 infection, supporting its important role in COVID-19. In fact, higher lipid peroxidation levels are independently associated to a higher risk of intubation or death at 28 days in COVID-19 patients.es
dc.format.mimetypeapplication/pdfes
dc.language.isospaes
dc.publisherelsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.titleLipid peroxidation as a hallmark of severity in COVID-19 patientses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/j.redox.2021.102181es
dc.identifier.publicationfirstpage102181es
dc.identifier.publicationtitleRedox Biologyes
dc.identifier.publicationvolume48es
dc.peerreviewedSIes
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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