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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/64526

    Título
    Lipid peroxidation as a hallmark of severity in COVID-19 patients
    Autor
    Martín Fernández, MartaAutoridad UVA Orcid
    Aller de la Fuente, RocíoAutoridad UVA Orcid
    Heredia Rodríguez, MaríaAutoridad UVA
    Gómez Sánchez, EstherAutoridad UVA
    Martínez de Paz, Pedro JoséAutoridad UVA
    Gonzalo Benito, HugoAutoridad UVA
    Sánchez de Prada, Laura
    Gorgojo Galindo, ÓscarAutoridad UVA Orcid
    Carnicero Frutos, Irene
    Tamayo Gómez, EduardoAutoridad UVA
    Tamayo Velasco, ÁlvaroAutoridad UVA Orcid
    Año del Documento
    2021
    Editorial
    elsevier
    Documento Fuente
    Redox Biol. 2021 Nov 6;48:102181
    Abstract
    Background: Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in response to infections. A defective redox balance has been related to viral pathogenesis developing a massive induction of cell death provoked by oxidative stress. The aim of this study is to perform a complete oxidative stress profile evaluation regarding antioxidant enzymes, total antioxidant capacity and oxidative cell damage in order to characterize its role in diagnosis and severity of this disease. Methods: Blood samples were obtained from 108 COVID-19 patients and 28 controls and metabolites representative of oxidative stress were assessed. The association between lipid peroxidation and 28-day intubation/death risk was evaluated by multivariable regression analysis. Probability of intubation/death to day-28 was analyzed by using Kaplan-Meier curves and tested with the log-rank test. Results: Antioxidant enzymes (Superoxide dismutase (SOD) and Catalase) and oxidative cell damage (Carbonyl and Lipid peroxidation (LPO)) levels were significantly higher in COVID-19 patients while total antioxidant capacity (ABTS and FRAP) levels were lower in these patients. The comparison of oxidative stress molecules’ levels across COVID-19 severity revealed that only LPO was statistically different between mild and intubated/ death COVID-19 patients. COX multivariate regression analysis identified LPO levels over the OOP (LPO>1948.17 μM) as an independent risk factor for 28-day intubation/death in COVID-19 patients [OR: 2.57; 95% CI: 1.10–5.99; p = 0.029]. Furthermore, Kaplan-Meier curve analysis revealed that COVID-19 patients showing LPO levels above 1948.17 μM were intubated or died 8.4 days earlier on average (mean survival time 15.4 vs 23.8 days) when assessing 28-day intubation/death risk (p < 0.001). Conclusion: These findings deepen our knowledge of oxidative stress status in SARS-CoV-2 infection, supporting its important role in COVID-19. In fact, higher lipid peroxidation levels are independently associated to a higher risk of intubation or death at 28 days in COVID-19 patients.
    ISSN
    2213-2317
    Revisión por pares
    SI
    DOI
    10.1016/j.redox.2021.102181
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/64526
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • DEP52 - Artículos de revista [181]
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