The Polymorphism rs17300539 in the Adiponectin Promoter Gene Is Related to Metabolic Syndrome, Insulin Resistance, and Adiponectin Levels in Caucasian Patients with Obesity

Abstract

BackgroundandAims:ThepresentstudywasdesignedtoinvestigateSNPrs17300539in theADIPOQgeneanditsrelationshipswithobesity,metabolicsyndrome(MS),andserumcirculating adiponectin.Methods:ThepresentdesigninvolvedaCaucasianpopulationof329subjectswith obesity.Anthropometricandadiposityparameters,bloodpressure,biochemicalparameters,and thepercentageofpatientswithmetabolicsyndromewererecorded. TheADIPOQgenevariant (rs17300539)genotypewasevaluated.Results:Thepercentageofpatientswithdifferentgenotypes of thers17300539polymorphisminthissamplewas86.0%(n=283) (GG),11.2%(n=37) (GA), and2.7%(n=9)(AA).TheallelefrequencywasG(0.76)andA(0.24). Applyingthedominant geneticmodel(GGvs.GA+AA),wereporteddifferencesbetweengenotypeGGandgenotype GA+AAforserumadiponectinlevels(Delta: 7.5±1.4ng/mL;p=0.03), triglycerides(Delta: 41.1±3.4mg/dL;p=0.01),fastingcirculatinginsulin(Delta:4.9±1.1mUI/L;p=0.02),andinsulin resistanceasHOMA-IR(Delta:1.4±0.1units;p=0.02).Theremainingbiochemicalparameterswere notrelatedtothegenotypeofobesepatients.ThepercentagesofindividualswithMS(OR=2.07, 95%CI=1.3–3.88;p=0.01),hypertriglyceridaemia(OR=2.66,95%CI=1.43–5.01;p=0.01),and hyperglycaemia(OR=3.31,95%CI=1.26–8.69;p=0.02)werehigherinGGsubjectsthanpatients withAallele.Logisticregressionanalysisreportedanimportantriskofthepresenceofmetabolic syndromeinGGsubjects(OR=1.99,95%CI=1.21–4.11;p=0.02)afteradjustingforadiponectin, dietaryenergyintakes,gender,weight,andage.Conclusions:TheGGgenotypeofrs17300539is associatedwithhypertriglyceridaemia,insulinresistance,lowadiponectinlevels,andahighriskof metabolicsyndromeanditscomponents.