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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/64891

    Título
    FGF2/EGF contributes to brain neuroepithelial precursor proliferation and neurogenesis in rat embryos: the involvement of embryonic cerebrospinal fluid
    Autor
    Martín Llorente, María Cristina
    Mano Bonín, Anibal de laAutoridad UVA
    Lamus Molina, José FranciscoAutoridad UVA
    Carnicero Gila, Estela MaríaAutoridad UVA Orcid
    Moro Balbás, José AntonioAutoridad UVA Orcid
    Fernández Gómez, José María FidelAutoridad UVA
    Gato Casado, Ángel LuisAutoridad UVA Orcid
    Alonso Revuelta, María IsabelAutoridad UVA Orcid
    Año del Documento
    2019
    Editorial
    Wiley
    Descripción
    Producción Científica
    Documento Fuente
    Developmental Dynamics, 2020, vol. 249, n. 1, p. 141-153
    Résumé
    Background: At the earliest stages of brain development, the neuroepithelium works as an interdependent functional entity together with cerebrospinal fluid, which plays a key regulatory role in neuroepithelial cell survival, replication and neurogenesis; however, the underlying mechanism remains unknown in mammals. Results: We show the presence of fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF), in 13.5-day rat embryo cerebrospinal fluid (eCSF). Immunohistochemical detection of FGF2 expression localized this factor inside neuroepithelial precursors close to the neuroepithelial-CSF interface, suggesting that FGF2 from eCSF could originate in the neuroepithelium by apical secretion. The colocalization of FGFR1 and FGF2 in some neuroepithelial cells close to the ventricular surface suggests they are target cells for eCSF FGF2. Brain neuroepithelium EGF expression was negative. By using a neuroepithelial organotypic culture, we demonstrate that FGF2 and EGF from eCSF plays a specific role in triggering the self-renewal and are involved in neurogenetic induction of mesencephalic neuroepithelial precursor cells during rat development. Conclusions: We propose eCSF as an intercommunication medium for neuroepithelial precursor behavior control during early rat brain development, and the neuroepithelial regulation of FGF2 and EGF presence in eCSF, as a regulative mechanism controlling precursor proliferation and neurogenesis.
    Materias (normalizadas)
    Neurología del desarrollo
    Palabras Clave
    EGF
    FGF2
    Precursores neuronales
    Mitogénesis
    Neurogénesis
    ISSN
    1058-8388
    Revisión por pares
    SI
    DOI
    10.1002/dvdy.135
    Patrocinador
    Junta de Castilla y León, Consejería de educación, Grant/Award Number: GR195; Ministerio de Educación y Ciencia, Grant/ Award Number: BFU207/6516
    Version del Editor
    https://anatomypubs.onlinelibrary.wiley.com/doi/epdf/10.1002/dvdy.135
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/64891
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP05 - Artículos de revista [198]
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    5 FGF2 EGF contributes to brain neuroepithelial precursor proliferation and.pdf
    Tamaño:
    2.212Mo
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    Attribution-NonCommercial-NoDerivatives 4.0 InternacionalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 Internacional

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