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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/64965

    Título
    Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study
    Autor
    Gálvez Fernandez, Marta
    Grau Pérez, María
    García Barrera, Tamara
    Ramírez Acosta, Sara
    Gómez Ariza, José L.
    Pérez Gómez, Beatriz
    Galán Labaca, Iñaki
    Navas Acién, Ana
    Redón Mas, Josep
    Briongos Figuero, Laisa SocorroAutoridad UVA Orcid
    Dueñas Laita, AntonioAutoridad UVA
    Pérez Castrillon, José LuisAutoridad UVA
    Téllez Plaza, Maria
    Martín Escudero, Juan CarlosAutoridad UVA
    Año del Documento
    2021
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Free Radical Biology and Medicine, Enero 2021, vol.162, p. 392-400.
    Resumen
    Background and objectives: Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association betweenAs, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representativesample of a general population from Spain. As secondary analyses we evaluated the associations of interest in subgroups defined by well-established BMD determinants, and also conducted prospective analysis of osteoporosis-related incident bone fractures restricted to participants older than 50 years-old. Methods: In N = 1365 Hortega Study participants >20 years-old, urine As and Cd were measured by inductively coupled-plasma mass spectrometry (ICPMS); plasma Se was measured by atomic absorption spectrometry (AAS) with graphite furnace; and BMD at the calcaneus was measured using the Peripheral Instaneuous X-ray Imaging system (PIXI). As levels were corrected for arsenobetaine (Asb) to account for inorganic As exposure. Results: The median of total urine As, Asb-corrected urine As, urine Cd, and plasma Se was 61.3, 6.53 and 0.39 μg/g creatinine, and 84.9 μg/L, respectively. In cross-sectional analysis, urine As and Cd were not associated with reduced BMD (T-score < -1 SD). We observed a non-linear dose-response of Se and reduced BMD, showing an inverse association below ~105 μg/L, which became increasingly positive above ~105 μg/L. The evaluated subgroups did not show differential associations. In prospective analysis, while we also observed a U-shape doseresponse of Se with the incidence of osteoporosis-related bone fractures, the positive association above ~105 μg/L was markedly stronger, compared to the cross-sectional analysis. Conclusions: Our results support that Se, but not As and Cd, was associated to BMD-related disease. The association of Se and BMD-related disease was non-linear, including a strong positive association with osteoporosisrelated bone fractures risk at the higher Se exposure range. Considering the substantial burden of bone loss in elderly populations, additional large prospective studies are needed to confirm the relevance of our findings to bone loss prevention in the population depending on Se exposure levels.
    Materias Unesco
    3205.02 Endocrinología
    Palabras Clave
    Bone mineral density
    Arsenic
    Cadmium
    Selenium
    Osteoporosis
    ISSN
    0891-5849
    Revisión por pares
    SI
    DOI
    10.1016/j.freeradbiomed.2020.10.318
    Patrocinador
    This work was supported by the Strategic Action for Research in Health sciences [CP12/03080, PI15/00071, PI10/0082, PI13/01848, PI14/00874, PI16/01402 and PI11/00726], CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN) (CIBER-02-08-2009, CB06/03 and CB12/03/30016), the State Agency for Research (PID2019-108973RBC21 and C22), the Valencia Government (GRUPOS 03/101; PROMETEO/ 2009/029 and ACOMP/2013/039), the Castilla-Leon Government (GRS/279/A/08) and European Network of Excellence Ingenious Hypercare (EPSS- 037093) from the European Commission. The Strategic Action for Research in Health sciences, CIBEROBN are initiatives from Carlos III Health Institute Madrid and co-funded with European Funds for Regional Development (FEDER). The State Agency for Research and Carlos III Health Institute belong to the Spanish Ministry of Science and Innovation. MGP received the support of a fellowship from “la Caixa” Foundation (ID 100010434, fellowship code LCF/BQ/IN18/ 11660001).
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S0891584920315926
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/64965
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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