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dc.contributor.author | Serrano-Lorenzo, Pablo | |
dc.contributor.author | Gobelli, Dino | |
dc.contributor.author | Garrido-Moraga, Rocío | |
dc.contributor.author | Esteban-Amo, María J. | |
dc.contributor.author | Orduña, Antonio | |
dc.contributor.author | de la Fuente, Miguel A. | |
dc.contributor.author | Martín, Miguel A. | |
dc.contributor.author | López López, José Ramón | |
dc.contributor.author | Simarro Grande, María | |
dc.date.accessioned | 2024-01-30T11:49:37Z | |
dc.date.available | 2024-01-30T11:49:37Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | PLoS ONE, 18(9 September), 1–15. | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/65304 | |
dc.description.abstract | Increasing evidence demonstrate that the electron transfer chain plays a critical role in controlling the effector functions of macrophages. In this work, we have generated a Ndufs4−/− murine macrophage cell lines. The Ndufs4 gene, which encodes a supernumerary subunit of complex I, is a mutational hotspot in Leigh syndrome patients. Ndufs4−/− macrophages showed decreased complex I activity, altered complex I assembly, and lower levels of maximal respiration and ATP production. These mitochondrial respiration alterations were associated with a shift towards a pro-inflammatory cytokine profile after lipopolysaccharide challenge and improved ability to phagocytose Gram-negative bacteria. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | spa | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.title | Development of a novel in vitro model to study the modulatory role of the respiratory complex I in macrophage effector functions | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1371/journal.pone.0291442 | es |
dc.identifier.publicationfirstpage | e0291442 | es |
dc.identifier.publicationissue | 9 | es |
dc.identifier.publicationtitle | PLOS ONE | es |
dc.identifier.publicationvolume | 18 | es |
dc.peerreviewed | SI | es |
dc.identifier.essn | 1932-6203 | es |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |