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dc.contributor.authorBarceló, Antonia
dc.contributor.authorDe la Peña, Mónica
dc.contributor.authorAyllón, Olga
dc.contributor.authorVega-Agapito, M Victoria
dc.contributor.authorPiérola, Javier
dc.contributor.authorPérez, Gerardo
dc.contributor.authorGonzález, Constancio
dc.contributor.authorAlonso, Alberto
dc.contributor.authorAgustí, Alvar GN
dc.date.accessioned2024-02-02T23:27:13Z
dc.date.available2024-02-02T23:27:13Z
dc.date.issued2009-10
dc.identifier.citationRespiration, octubre 2009, vol. 77, p.85-90es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/65609
dc.descriptionProducción Científicaes
dc.description.abstractCardiovascular (CV) diseases are a leading cause of mortality and they are frequent in patients with the obstructive sleep apnea syndrome (OSAS). Objectives: In this study we investigated if OSAS influences CV function independently of other CV risk factors frequently present in these patients (e.g. obesity, high blood pressure). Methods: We compared plasma markers of endothelial dysfunction, asymmetric dimethylarginine (ADMA) and endothelin-1 (ET- 1), and atherosclerosis progression (soluble fraction of the CD40 ligand, sCD40L) in OSAS patients with (n = 23) and without (n = 18) concurrent CV risk factors, as well as in healthy subjects (n = 23). Results: Plasma ADMA (p ! 0.01) and sCD40L (p ! 0.05) were abnormally increased in patients with OSAS versus healthy controls, but they were not influenced by the presence or absence of CV risk factors in OSAS. ET-1 levels were not different between the three groups of subjects studied. Conclusions: OSAS is associated with endothelial injury and atherosclerosis progression independently of other CV risk factors.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherKargeres
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccesses
dc.subject.classificationSleep apnea, Biomarkers, Endothelial dysfunction, Atherosclerosis, Obesityes
dc.titleIncreased Plasma Levels of Asymmetric Dimethylarginine and Soluble CD40 Ligand in Patients with Sleep Apneaes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holderKargeres
dc.identifier.doihttps://doi.org/10.1159/000165630es
dc.relation.publisherversionhttps://karger.com/res/article-abstract/77/1/85/289644/Increased-Plasma-Levels-of-Asymmetric?redirectedFrom=fulltextes
dc.identifier.publicationfirstpage85es
dc.identifier.publicationlastpage90es
dc.identifier.publicationvolume77es
dc.peerreviewedSIes
dc.description.projectEste trabajo fue fianciado en parte por ABEMAR, SEPAR, Marató TV3 04/2410 and Fondo de Investigaciones Sanitarias 04/1593.es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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