dc.contributor.author | Barceló, Antonia | |
dc.contributor.author | De la Peña, Mónica | |
dc.contributor.author | Ayllón, Olga | |
dc.contributor.author | Vega-Agapito, M Victoria | |
dc.contributor.author | Piérola, Javier | |
dc.contributor.author | Pérez, Gerardo | |
dc.contributor.author | González, Constancio | |
dc.contributor.author | Alonso, Alberto | |
dc.contributor.author | Agustí, Alvar GN | |
dc.date.accessioned | 2024-02-02T23:27:13Z | |
dc.date.available | 2024-02-02T23:27:13Z | |
dc.date.issued | 2009-10 | |
dc.identifier.citation | Respiration, octubre 2009, vol. 77, p.85-90 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/65609 | |
dc.description | Producción Científica | es |
dc.description.abstract | Cardiovascular (CV) diseases are a leading
cause of mortality and they are frequent in patients with the
obstructive sleep apnea syndrome (OSAS). Objectives: In
this study we investigated if OSAS influences CV function
independently of other CV risk factors frequently present in
these patients (e.g. obesity, high blood pressure). Methods:
We compared plasma markers of endothelial dysfunction,
asymmetric dimethylarginine (ADMA) and endothelin-1 (ET-
1), and atherosclerosis progression (soluble fraction of the
CD40 ligand, sCD40L) in OSAS patients with (n = 23) and
without (n = 18) concurrent CV risk factors, as well as in
healthy subjects (n = 23). Results: Plasma ADMA (p ! 0.01)
and sCD40L (p ! 0.05) were abnormally increased in patients
with OSAS versus healthy controls, but they were not influenced
by the presence or absence of CV risk factors in OSAS.
ET-1 levels were not different between the three groups of
subjects studied. Conclusions: OSAS is associated with endothelial
injury and atherosclerosis progression independently
of other CV risk factors. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Karger | es |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | es |
dc.subject.classification | Sleep apnea, Biomarkers, Endothelial dysfunction, Atherosclerosis, Obesity | es |
dc.title | Increased Plasma Levels of Asymmetric Dimethylarginine and Soluble CD40 Ligand in Patients with Sleep Apnea | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | Karger | es |
dc.identifier.doi | https://doi.org/10.1159/000165630 | es |
dc.relation.publisherversion | https://karger.com/res/article-abstract/77/1/85/289644/Increased-Plasma-Levels-of-Asymmetric?redirectedFrom=fulltext | es |
dc.identifier.publicationfirstpage | 85 | es |
dc.identifier.publicationlastpage | 90 | es |
dc.identifier.publicationvolume | 77 | es |
dc.peerreviewed | SI | es |
dc.description.project | Este trabajo fue fianciado en parte por ABEMAR, SEPAR, Marató TV3 04/2410 and Fondo de Investigaciones Sanitarias 04/1593. | es |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |