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    • Dpto. Bioquímica y Biología Molecular y Fisiología
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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65826

    Título
    Calcium Permeable Channels in Cancer Hallmarks
    Autor
    Tajada Esteban, SendoaAutoridad UVA
    Villalobos, Carlos
    Año del Documento
    2020
    Documento Fuente
    Front Pharmacol. 2020 Jul 7;11:968.
    Resumen
    Cancer, the second cause of death worldwide, is characterized by several common criteria, known as the "cancer hallmarks" such as unrestrained cell proliferation, cell death resistance, angiogenesis, invasion and metastasis. Calcium permeable channels are proteins present in external and internal biological membranes, diffusing Ca2+ ions down their electrochemical gradient. Numerous physiological functions are mediated by calcium channels, ranging from intracellular calcium homeostasis to sensory transduction. Consequently, calcium channels play important roles in human physiology and it is not a surprise the increasing number of evidences connecting calcium channels disorders with tumor cells growth, survival and migration. Multiple studies suggest that calcium signals are augmented in various cancer cell types, contributing to cancer hallmarks. This review focuses in the role of calcium permeable channels signaling in cancer with special attention to the mechanisms behind the remodeling of the calcium signals. Transient Receptor Potential (TRP) channels and Store Operated Channels (SOC) are the main extracellular Ca2+ source in the plasma membrane of non-excitable cells, while inositol trisphosphate receptors (IP3R) are the main channels releasing Ca2+ from the endoplasmic reticulum (ER). Alterations in the function and/or expression of these calcium channels, as wells as, the calcium buffering by mitochondria affect intracellular calcium homeostasis and signaling, contributing to the transformation of normal cells into their tumor counterparts. Several compounds reported to counteract several cancer hallmarks also modulate the activity and/or the expression of these channels including non-steroidal anti-inflammatory drugs (NSAIDs) like sulindac and aspirin, and inhibitors of polyamine biosynthesis, like difluoromethylornithine (DFMO). The possible role of the calcium permeable channels targeted by these compounds in cancer and their action mechanism will be discussed also in the review.
    Revisión por pares
    SI
    DOI
    10.3389/fphar.2020.00968
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/65826
    Tipo de versión
    info:eu-repo/semantics/draft
    Derechos
    openAccess
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    • DEP06 - Artículos de revista [352]
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    Tajada, Villalobos - 2020 - Calcium Permeable Channels in Cancer Hallmarks.pdf
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