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dc.contributor.author | Olea Fraile, Elena | |
dc.contributor.author | Ferrer, Elisabet | |
dc.contributor.author | Prieto Lloret, Jesús | |
dc.contributor.author | Gonzalez-Martin, Carmen | |
dc.contributor.author | Vega Agapito, María Victoria | |
dc.contributor.author | González Obeso, Elvira | |
dc.contributor.author | Agapito Serrano, María Teresa | |
dc.contributor.author | Peinado, Victor | |
dc.contributor.author | Obeso Cáceres, Ana María de la Luz | |
dc.contributor.author | Barbera, Joan Albert | |
dc.contributor.author | González Martínez, Constancio | |
dc.date.accessioned | 2024-02-06T19:22:40Z | |
dc.date.available | 2024-02-06T19:22:40Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Respiratory Physiology and Neurobiology, 2011, 179, p.305-313 | es |
dc.identifier.issn | 1569-9048 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/65863 | |
dc.description | Producción Científica | es |
dc.description.abstract | Previously we have reported that association of cigarette smoke (CS) and chronic hypoxia (CH) interact positively to physiopathologically remodel pulmonary circulation. In present study we have exposed guinea pigs to CS smoke (four cigarettes/day; 3 months; CS) and to chronic hypoxia (12% O2, 15 days; CH) alone or in combination (CSCH animals) and evaluated airways remodeling and resistance assessed as Penh (enhance pause). We measured Penh while animals breathe air, 10% O2 and 5% CO2 and found that CS and CH animals have higher Penh than controls; Penh was even larger in CSCH animals. A rough parallelism between Penh and thickness of bronchiolar wall and muscular layer and Goblet cell number was noticed. We conclude that CS and CH association accelerates CS-induced respiratory system damage, evidenced by augmented airway resistance, bronchial wall thickness and muscularization and Goblet cell number. Our findings would suggest that appearance of hypoxia would aggravate any preexisting pulmonary pathology by increasing airways resistance and reactivity. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | es |
dc.subject.classification | Guinea pig Tobacco smoke Hypoxia Airways remodeling Penh | es |
dc.title | Effects of cigarette smoke and chronic hypoxia on airways remodeling and resistance. Clinical significance | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | Elsevier | es |
dc.identifier.doi | 10.1016/j.resp.2011.09.013 | es |
dc.identifier.publicationfirstpage | 305 | es |
dc.identifier.publicationlastpage | 313 | es |
dc.identifier.publicationtitle | Respiratory Physiology & Neurobiology | es |
dc.identifier.publicationvolume | 179 | es |
dc.peerreviewed | SI | es |
dc.description.project | The work was supported by the “Ministerio de Ciencia e Innovación of Spain”, [grant number BFU2007-61848], by the “Instituto Carlos III”, [grant number CIBER CB06/06/0050] and by “Fondo de Investigación de la Seguridad Social”, [grant number FIS 04/1424]. | es |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |