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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/66248

    Título
    Mechanism of the lifespan extension induced by submaximal SERCA inhibition in C. elegans
    Autor
    García Casas, PalomaAutoridad UVA
    Álvarez Illera, María Pilar
    Fonteriz García, Rosalba InésAutoridad UVA Orcid
    Montero Zoccola, María TeresaAutoridad UVA Orcid
    Álvarez Martín, JavierAutoridad UVA Orcid
    Año del Documento
    2021
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Mechanisms of Ageing and Development, Marzo 2021, 196, 111474
    Resumen
    We have reported recently that submaximal inhibition of the Sarco Endoplasmic Reticulum Ca2+ ATPase (SERCA) produces an increase in the lifespan of C. elegans worms. We have explored here the mechanism of this increased survival by studying the effect of SERCA inhibition in several mutants of signaling pathways related to longevity. Our data show that the mechanism of the effect is unrelated with the insulin signaling pathway or the sirtuin activity, because SERCA inhibitors increased lifespan similarly in mutants of these pathways. However, the effect required functional mitochondria and both the AMP kinase and TOR pathways, as the SERCA inhibitors were ineffective in the corresponding mutants. The same effects were obtained after reducing SERCA expression with submaximal RNAi treatment. The SERCA inhibitors did not induce ER-stress at the concentrations used, and their effect was not modified by inactivation of the OP50 bacterial food. Altogether, our data suggest that the effect may be due to a reduced ER-mitochondria Ca2+ transfer acting via AMPK activation and mTOR inhibition to promote survival.
    Palabras Clave
    C. elegans, SERCA, Thapsigargin, Lifespan, Endoplasmic reticulum, Mitochondria, AMP kinase, TOR
    ISSN
    0047-6374
    Revisión por pares
    SI
    DOI
    10.1016/j.mad.2021.111474
    Patrocinador
    MICINN project BFU2017-83509-R
    Junta de Castilla y León project VA011G18
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S0047637421000464
    Propietario de los Derechos
    Elsevier Ltd.
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/66248
    Tipo de versión
    info:eu-repo/semantics/acceptedVersion
    Derechos
    restrictedAccess
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    • DEP06 - Artículos de revista [352]
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    Nombre:
    2021-Mech Age Dev-Final version.pdf
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