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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/67068

    Título
    25-hydroxyvitamin D serum levels linked to single-nucleotide polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in sports performance in CrossFit® elite athletes
    Autor
    Fernández Lázaro, DiegoAutoridad UVA
    Celorrio San Miguel, Ana M.
    Seco Calvo, Jesús
    Roche Collado, Enrique
    Fernández Lázaro, César I.
    Año del Documento
    2023
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Biology and Life Sciences Forum, 2023, Vol. 29, Nº. 1, 21
    Resumen
    Vitamin D substantially influences sports performance and post-exercise recovery because it offers anti-inflammatory, antioxidant and cellular protective properties. However, deficient levels of 25-hydroxyvitamin D 25(OH)D (25(OH)D) (<30 ng/mL) could impact the health of individuals, lead to musculoskeletal disorders and decrease athletic performance. Therefore, it would be appropriate to know the interactions between genes and vitamin D. We evaluated whether 25(OH)D had a possible connection to the presence of certain SNPs in CYP2R1 (rs10741657), GC (rs2282679) and muscle VDR (rs2228570) genes, with serum 25(OH)D concentrations and the degree of WOD performance in highly trained CrossFit® practitioners. Knowing these relationships could be instrumental for personalized vitamin D supplementation and training strategies. Using a standardized commercial enzyme-linked immunosorbent assay procedure, the concentrations of 25(OH)D were determined and the genotyping procedures for each SNPs were carried out using specific assays with the KASpar® test. The 25(OH)DA performance level in grades was established based on the CrossFit® Total score (sum in kilograms of one Repetition Max Squat, Press and Deadlift). Significant differences (p < 0.05) in 25(OH)D concentration were found between each of the SNPs of CYP2R1 and GC with 25(OH)D. We discovered statistically significant weak positive correlations (p < 0.05) between 25(OH)D and AA-alleles of the CYP2R1 and VDR genes, and TT-alleles of the GC gene. Additionally, AA (rs10741657 and rs2228570) and TT (rs2282679) have a probability between 2 and 4 of having major concentrations of 25(OH)D and 25(OH)D25(OH)D. Conversely, GG alleles present a probability of suboptimum values of 25(OH)D of 69%, 34% and 24% for VDR, GC and CYP2R1, respectively, showing a strong moderate positive correlation (r = 0.41) between the degrees of sports performance and 25(OH)D25(OH)D plasma levels. The different polymorphisms of our three candidate genes CYP2R1 (rs10741657), GC (rs2282679) and VDR (rs2228570) disturb 25(OH)D concentration and play a critical role in the sports performance of elite CrossFit® practitioners. These results could highlight that the evaluation of genetic factors is key to designing a vitamin D supplementation strategy to improve sports performance.
    Materias (normalizadas)
    Sports performance
    Sports - Physiological aspects
    Deportes - Aspectos fisiológicos
    Vitamina D
    Single nucleotide polymorphisms
    Genetics
    Genética
    Elite athletes
    Deportistas profesionales
    Entrenamiento deportivo
    Materias Unesco
    2302.32 Vitaminas
    2411.06 Fisiología del Ejercicio
    ISSN
    2673-9976
    Revisión por pares
    SI
    DOI
    10.3390/IECN2023-15799
    Patrocinador
    Plan TCUE de Castilla y León 2021-2023 - (grant 134/2021)
    Junta de Castilla y León y Fondo Europeo de Desarrollo Regional (FEDER) - (grant PI22/00008)
    Version del Editor
    https://www.mdpi.com/2673-9976/29/1/21
    Propietario de los Derechos
    © 2023 The authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/67068
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • DEP05 - Artículos de revista [198]
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