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[3H]Spiroperidol binding in normal and denervated carotid bodies
Año del Documento
Neuroscience Letters, 1981, 21, p. 51-55
Specific dopamine receptors were studied in freshly dissected, unhomogenized rabbit carotid bodies incubated in [3H]spiroperidol. Total binding and non-specific binding were determined in the absence and presence of 0.2 #M (+)-butaclamol, respectively. Specific binding in normal carotid bodies incubated at near saturating concentrations (0.38 nM) was 1.63 _+ 0.58 pmol/g of tissue. Chronic section of the carotid sinus nerve (14 days) resulted in a 64070 reduction (P < 0.05) in specific binding. We conclude that the majority of specific dopaminergic receptors are located on carotid sinus nerve afferent terminals.
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