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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/67281

    Título
    The mechanisms of regulated cell death: Structural and functional proteomic pathways induced or inhibited by a specific protein—A narrative review
    Autor
    Fernández Lázaro, DiegoAutoridad UVA
    Sanz, Begoña
    Seco Calvo, Jesús
    Año del Documento
    2024
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Proteomes, 2024, Vol. 12, Nº. 1, 3
    Abstract
    Billions of cells die in us every hour, and our tissues do not shrink because there is a natural regulation where Cell Death (CD) is balanced with cell division. The process in which cells eliminate themselves in a controlled manner is called Programmed Cell Death (PCD). The PCD plays an important role during embryonic development, in maintaining homeostasis of the body’s tissues, and in the elimination of damaged cells, under a wide range of physiological and developmental stimuli. A multitude of protein mediators of PCD have been identified and signals have been found to utilize common pathways elucidating the proteins involved. This narrative review focuses on caspase-dependent and caspase-independent PCD pathways. Included are studies of caspase-dependent PCD such as Anoikis, Catastrophe Mitotic, Pyroptosis, Emperitosis, Parthanatos and Cornification, and Caspase-Independent PCD as Wallerian Degeneration, Ferroptosis, Paraptosis, Entosis, Methuosis, and Extracellular Trap Abnormal Condition (ETosis), as well as neutrophil extracellular trap abnormal condition (NETosis) and Eosinophil Extracellular Trap Abnormal Condition (EETosis). Understanding PCD from those reported in this review could shed substantial light on the processes of biological homeostasis. In addition, identifying specific proteins involved in these processes is mandatory to identify molecular biomarkers, as well as therapeutic targets. This knowledge could provide the ability to modulate the PCD response and could lead to new therapeutic interventions in a wide range of diseases.
    Materias (normalizadas)
    Programmed cell death
    Cell death
    Células - Muerte
    Caspases
    Mitotic catastrophe
    Pyroptosis
    Parthanatos
    Nervous system - Degeneration
    Sistema nervioso - Degeneración
    Ferroptosis
    Entosis
    Proteomics
    Proteòmica
    Proteins
    Cell Biology
    Materias Unesco
    2302.27 Proteínas
    2407 Biología Celular
    ISSN
    2227-7382
    Revisión por pares
    SI
    DOI
    10.3390/proteomes12010003
    Patrocinador
    Junta de Castilla y León, Consejería de Educación y Fondo Europeo de Desarrollo Regional (FEDER) - (Plan TCUE 2021-2023, 134/2021) - (grant SO002P23)
    Version del Editor
    https://www.mdpi.com/2227-7382/12/1/3
    Propietario de los Derechos
    © 2024 The authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/67281
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • DEP05 - Artículos de revista [198]
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