Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/67281
Título
The mechanisms of regulated cell death: Structural and functional proteomic pathways induced or inhibited by a specific protein—A narrative review
Año del Documento
2024
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Proteomes, 2024, Vol. 12, Nº. 1, 3
Abstract
Billions of cells die in us every hour, and our tissues do not shrink because there is a natural regulation where Cell Death (CD) is balanced with cell division. The process in which cells eliminate themselves in a controlled manner is called Programmed Cell Death (PCD). The PCD plays an important role during embryonic development, in maintaining homeostasis of the body’s tissues, and in the elimination of damaged cells, under a wide range of physiological and developmental stimuli. A multitude of protein mediators of PCD have been identified and signals have been found to utilize common pathways elucidating the proteins involved. This narrative review focuses on caspase-dependent and caspase-independent PCD pathways. Included are studies of caspase-dependent PCD such as Anoikis, Catastrophe Mitotic, Pyroptosis, Emperitosis, Parthanatos and Cornification, and Caspase-Independent PCD as Wallerian Degeneration, Ferroptosis, Paraptosis, Entosis, Methuosis, and Extracellular Trap Abnormal Condition (ETosis), as well as neutrophil extracellular trap abnormal condition (NETosis) and Eosinophil Extracellular Trap Abnormal Condition (EETosis). Understanding PCD from those reported in this review could shed substantial light on the processes of biological homeostasis. In addition, identifying specific proteins involved in these processes is mandatory to identify molecular biomarkers, as well as therapeutic targets. This knowledge could provide the ability to modulate the PCD response and could lead to new therapeutic interventions in a wide range of diseases.
Materias (normalizadas)
Programmed cell death
Cell death
Células - Muerte
Caspases
Mitotic catastrophe
Pyroptosis
Parthanatos
Nervous system - Degeneration
Sistema nervioso - Degeneración
Ferroptosis
Entosis
Proteomics
Proteòmica
Proteins
Cell Biology
Materias Unesco
2302.27 Proteínas
2407 Biología Celular
ISSN
2227-7382
Revisión por pares
SI
Patrocinador
Junta de Castilla y León, Consejería de Educación y Fondo Europeo de Desarrollo Regional (FEDER) - (Plan TCUE 2021-2023, 134/2021) - (grant SO002P23)
Version del Editor
Propietario de los Derechos
© 2024 The authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
Collections
Files in this item
![Atribución 4.0 Internacional](/themes/Mirage2//images/creativecommons/cc-by.png)