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    Citas

    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/6842

    Título
    Correlation Between Adenosine Triphosphate Levels, Dopamine Release and Electrical Activity in the Carotid Body: Support for the Metabolic Hypothesis of Chemoreception
    Autor
    Obeso Cáceres, Ana María de la LuzAutoridad UVA Orcid
    Almaraz Gómez, LauraAutoridad UVA
    González Martínez, Constancio
    Año del Documento
    1985
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Brain Research, 1985, vol. 348, p.64-68
    Résumé
    An unsolved issue for the arterial chemoreceptors is the mechanism by which hypoxia and other natural stimuli lead to an increase of activity in the carotid sinus nerve. According to the 'metabolic hypothesis', the hypoxic activation of the carotid body (CB) is mediated by a decrease of the ATP levels in the type I cells, which then release a neurotransmitter capable of exciting the sensory nerve endings. Using an in vitro preparation of cat CB, we report that ATP levels in the CB do in fact decrease when the organs are exposed to moderate, short lasting hypoxia (5 min 20% 02). Additionally, we found that decreases in ATP levels induced by 2-deoxyglucose (2 mM) or sodium cyanide (0.1 raM) are closely correlated with dopamine release from type I cells and electrical activity in the carotid sinus nerve elicited by these agents. The possible cause-effect relationship of these events is discussed
    Materias (normalizadas)
    Neurofisiología
    ISSN
    0006-8993
    Revisión por pares
    Sí
    DOI
    10.1016/0006-8993(85)90360-9
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/6842
    Derechos
    openAccess
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    • DEP06 - Artículos de revista [353]
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    Descripción:
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

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