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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/6852

    Título
    Tetrodotoxin as a Tool to Elucidate Sensory Transduction Mechanisms: The Case for the Arterial Chemoreceptors of the Carotid Body
    Autor
    Rocher Martín, María AsunciónAutoridad UVA Orcid
    Cáceres Pereira, Ana IsabelAutoridad UVA
    Obeso Cáceres, Ana María de la LuzAutoridad UVA Orcid
    González Martínez, Constancio
    Año del Documento
    2011
    Editorial
    Multidisciplinary Digital Publishing Institute
    Descripción
    Producción Científica
    Documento Fuente
    Marine Drugs, 9(2011) 2683-2704
    Résumé
    Abstract: Carotid bodies (CBs) are secondary sensory receptors in which the sensing elements, chemoreceptor cells, are activated by decreases in arterial PO2 (hypoxic hypoxia). Upon activation, chemoreceptor cells (also known as Type I and glomus cells) increase their rate of release of neurotransmitters that drive the sensory activity in the carotid sinus nerve (CSN) which ends in the brain stem where reflex responses are coordinated. When challenged with hypoxic hypoxia, the physiopathologically most relevant stimulus to the CBs, they are activated and initiate ventilatory and cardiocirculatory reflexes. Reflex increase in minute volume ventilation promotes CO2 removal from alveoli and a decrease in alveolar PCO2 ensues. Reduced alveolar PCO2 makes possible alveolar and arterial PO2 to increase minimizing the intensity of hypoxia. The ventilatory effect, in conjunction the cardiocirculatory components of the CB chemoreflex, tend to maintain an adequate supply of oxygen to the tissues. The CB has been the focus of attention since the discovery of its nature as a sensory organ by de Castro (1928) and the discovery of its function as the origin of ventilatory reflexes by Heymans group (1930). A great deal of effort has been focused on the study of the mechanisms involved in O2 detection. This review is devoted to this topic, mechanisms of oxygen sensing. Starting from a summary of the main theories evolving through the years, we will emphasize the nature and significance of the findings obtained with veratridine and tetrodotoxin (TTX) in the genesis of current models of O2-sensing.
    Materias (normalizadas)
    Neurofisiología
    ISSN
    1660-3397
    Revisión por pares
    SI
    DOI
    10.3390/md9122683
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/6852
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [353]
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    Descripción:
    PD-173
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

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