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dc.contributor.author | Sarisoy, Alp | |
dc.contributor.author | Acosta Rodríguez, Sergio | |
dc.contributor.author | Rodríguez Cabello, José Carlos | |
dc.contributor.author | Czichowski, Phillip | |
dc.contributor.author | Kopp, Alexander | |
dc.contributor.author | Jockenhoevel, Stefan | |
dc.contributor.author | Fernández Colino, Alicia | |
dc.date.accessioned | 2024-07-26T08:43:35Z | |
dc.date.available | 2024-07-26T08:43:35Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | International Journal of Molecular Sciences, 2023, Vol. 24, Nº. 7, 6776 | es |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/69182 | |
dc.description | Producción Científica | es |
dc.description.abstract | More than 260 million surgical procedures are performed worldwide each year. Although sutures and staples are widely used to reconnect tissues, they can cause further damage and increase the risk of infection. Bioadhesives have been proposed as an alternative to reconnect tissues. However, clinical adhesives that combine strong adhesion with cytocompatibility have yet to be developed. In this study, we explored the production of adhesives based on protein-engineered polymers bioinspired by the sequence of elastin (i.e., elastin-like recombinamers, ELRs). We hypothesized that the combination of polyphenols (i.e., tannic acid, TA) and ELRs would produce an adhesive coacervate (ELR+TA), as reported for other protein polymers such as silk fibroin (SF). Notably, the adhesion of ELR alone surpassed that of ELR+TA. Indeed, ELR alone achieved adhesive strengths of 88.8 ± 33.2 kPa and 17.0 ± 2.0 kPa on porcine bone and skin tissues, respectively. This surprising result led us to explore a multicomponent bioadhesive to encompass the complementary roles of elastin (mimicked here by ELR) and silk fibroin (SF), and subsequently mirror more closely the multicomponent nature of the extracellular matrix. Tensile testing showed that ELR+SF achieved an adhesive strength of 123.3 ± 60.2 kPa on porcine bone and excellent cytocompatibility. To express this in a more visual and intuitive way, a small surface of only 2.5 cm2 was able to lift at least 2 kg of weight. This opens the door for further studies focusing on the ability of protein-engineered polymers to adhere to biological tissues without further chemical modification for applications in tissue engineering. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Adhesives | es |
dc.subject | Adhesivos | es |
dc.subject | Biomaterials | es |
dc.subject | Biomateriales | es |
dc.subject | Biomedical materials | es |
dc.subject | Polymers | es |
dc.subject | Proteins | es |
dc.subject | Medicine | es |
dc.subject | Polímeros recombinantes | es |
dc.subject | Tejidos (Histología) | es |
dc.subject | Bones | es |
dc.subject | Huesos | es |
dc.subject | Skin | es |
dc.subject | Piel | es |
dc.subject | Organic chemistry | es |
dc.subject | Inorganic chemistry | es |
dc.subject | Molecular biology | es |
dc.subject | Medical technology | es |
dc.title | Bioglues based on an elastin-like recombinamer: effect of tannic acid as an additive on tissue adhesion and cytocompatibility | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2023 The authors | es |
dc.identifier.doi | 10.3390/ijms24076776 | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/24/7/6776 | es |
dc.identifier.publicationfirstpage | 6776 | es |
dc.identifier.publicationissue | 7 | es |
dc.identifier.publicationtitle | International Journal of Molecular Sciences | es |
dc.identifier.publicationvolume | 24 | es |
dc.peerreviewed | SI | es |
dc.description.project | Gobiernos federal y estatal de Alemania - (StUpPD370-20) | es |
dc.description.project | Ministerio Alemán de Educación e Investigación (BMBF) - (grant 13XP5136) | es |
dc.description.project | Gobierno de España - (grant PID2019- 110709RB-100, RED2018-102417-T) | es |
dc.description.project | Junta de Castilla y León - (grant VA317P18, Infrared2018-UVA06) | es |
dc.description.project | Programa de Cooperación Interreg España-Portugal POCTEP - (grant 0624_2IQBIONEURO_6_E) | es |
dc.identifier.essn | 1422-0067 | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
dc.subject.unesco | 2206.10 Polímeros | es |
dc.subject.unesco | 2302.27 Proteínas | es |
dc.subject.unesco | 2306 Química Orgánica | es |
dc.subject.unesco | 2303 Química Inorgánica | es |
dc.subject.unesco | 32 Ciencias Médicas | es |
dc.subject.unesco | 2415 Biología Molecular | es |
dc.subject.unesco | 3314 Tecnología Médica | es |
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