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dc.contributor.author | Gabriel, Rafael | |
dc.contributor.author | Boukichou Abdelkader, Nisa | |
dc.contributor.author | Gilis-Januszewska, Aleksandra | |
dc.contributor.author | Makrilakis, Konstantinos | |
dc.contributor.author | Gómez Huelgas, Ricardo | |
dc.contributor.author | Kamenov, Zdravko | |
dc.contributor.author | Paulweber, Bernhard | |
dc.contributor.author | Satman, Ilhan | |
dc.contributor.author | Djordjevic, Predrag | |
dc.contributor.author | Alkandari, Abdullah | |
dc.contributor.author | Mitrakou, Asimina | |
dc.contributor.author | Lalic, Nebojsa | |
dc.contributor.author | Egido, Jesús | |
dc.contributor.author | Más Fontao, Sebastián | |
dc.contributor.author | Calvet, Jean Henri | |
dc.contributor.author | Pastor Jimeno, José Carlos | |
dc.contributor.author | Lindström, Jaana | |
dc.contributor.author | Lind, Marcus | |
dc.contributor.author | Acosta, Tania | |
dc.contributor.author | Silva, Luis | |
dc.contributor.author | Tuomilehto, Jaakko | |
dc.date.accessioned | 2024-07-30T10:53:01Z | |
dc.date.available | 2024-07-30T10:53:01Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Journal of Clinical Medicine, 2023, Vol. 12, Nº. 5, 2035 | es |
dc.identifier.issn | 2077-0383 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/69310 | |
dc.description | Producción Científica | es |
dc.description.abstract | Objective: To compare the effect of glucose-lowering drugs on peripheral nerve and kidney function in prediabetes. Methods: Multicenter, randomized, placebo-controlled trial in 658 adults with prediabetes treated for 1 year with metformin, linagliptin, their combination or placebo. Endpoints are small fiber peripheral neuropathy (SFPN) risk estimated by foot electrochemical skin conductance (FESC < 70 μSiemens) and estimated glomerular filtration rate (eGFR). Results: Compared to the placebo, the proportion of SFPN was reduced by 25.1% (95% CI:16.3–33.9) with metformin alone, by 17.3% (95% CI 7.4–27.2) with linagliptin alone, and by 19.5% (95% CI 10.1–29.0) with the combination linagliptin/metformin (p < 0.0001 for all comparisons). eGFR remained +3.3 mL/min (95% CI: 0.38–6.22) higher with the combination linagliptin/metformin than with the placebo (p = 0.03). Fasting plasma glucose (FPG) decreased more with metformin monotherapy −0.3 mmol/L (95%CI: −0.48; 0.12, p = 0.0009) and with the combination metformin/linagliptin −0.2 mmol/L (95% CI: −0.37; −0.03) than with the placebo (p = 0.0219). Body weight (BW) decreased by −2.0 kg (95% CI: −5.65; −1.65, p = 0.0006) with metformin monotherapy, and by −1.9 kg (95% CI: −3.02; −0.97) with the combination metformin/linagliptin as compared to the placebo (p = 0.0002). Conclusions: in people with prediabetes, a 1 year treatment with metformin and linagliptin, combined or in monotherapy, was associated with a lower risk of SFPN, and with a lower decrease in eGFR, than treatment with placebo. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Diabetes - Diagnosis | es |
dc.subject | Diabetes - Prevention | es |
dc.subject | Diabetes - Prevención | es |
dc.subject | Diabetes - Treatment | es |
dc.subject | Diabetes - Tratamiento | es |
dc.subject | Nervous system - Diseases | es |
dc.subject | Nervioso, Sistema - Enfermedades | es |
dc.subject | Sistema nervioso periférico - Enfermedades | es |
dc.subject | Neuropatia | es |
dc.subject | Neurology | es |
dc.subject | Kidneys - Diseases | es |
dc.subject | Riñones - Enfermedades | es |
dc.subject | Pharmacology | es |
dc.subject | Drugs | es |
dc.subject | Medicamentos | es |
dc.subject | Lifestyle | es |
dc.subject | Calidad de vida | es |
dc.subject | Clinical trials | es |
dc.subject | Ensayos clínicos | es |
dc.subject | Public health | es |
dc.title | Reduction in the risk of peripheral neuropathy and lower decrease in kidney function with metformin, linagliptin or their fixed-dose combination compared to placebo in prediabetes: a randomized controlled trial | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2023 The authors | es |
dc.identifier.doi | 10.3390/jcm12052035 | es |
dc.relation.publisherversion | https://www.mdpi.com/2077-0383/12/5/2035 | es |
dc.identifier.publicationfirstpage | 2035 | es |
dc.identifier.publicationissue | 5 | es |
dc.identifier.publicationtitle | Journal of Clinical Medicine | es |
dc.identifier.publicationvolume | 12 | es |
dc.peerreviewed | SI | es |
dc.description.project | Comisión Europea - (FP7 EC-GA: 279074) | es |
dc.description.project | Boeringher Ingelheim, Germany. IIS Program - (grant 1218.166) | es |
dc.description.project | Merck Healthcare KGaA, Darmstadt, Germany - (grant EMR200084_621) | es |
dc.description.project | Instituto de Salud Carlos III - (grant PI11/01653) | es |
dc.identifier.essn | 2077-0383 | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
dc.subject.unesco | 32 Ciencias Médicas | es |
dc.subject.unesco | 3205.07 Neurología | es |
dc.subject.unesco | 3209 Farmacología | es |
dc.subject.unesco | 3212 Salud Publica | es |
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