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dc.contributor.author | Aparisi Sanz, Álvaro | |
dc.contributor.author | Martín Fernández, Marta | |
dc.contributor.author | Ybarra Falcón, Cristina | |
dc.contributor.author | Gil, José Francisco | |
dc.contributor.author | Carrasco Moraleja, Manuel | |
dc.contributor.author | Martínez de Paz, Pedro José | |
dc.contributor.author | Cusácovich Torres, Iván | |
dc.contributor.author | Gonzalo Benito, Hugo | |
dc.contributor.author | Fuertes, Raúl | |
dc.contributor.author | Marcos Mangas, Marta | |
dc.contributor.author | Iglesias Echeverría, Carolina | |
dc.contributor.author | San Román Calvar, José Alberto | |
dc.contributor.author | Tamayo Gómez, Eduardo | |
dc.contributor.author | Andaluz Ojeda, David | |
dc.contributor.author | Tamayo Velasco, Álvaro | |
dc.date.accessioned | 2024-09-10T08:25:31Z | |
dc.date.available | 2024-09-10T08:25:31Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | International Journal of Molecular Sciences, 2022, Vol. 23, Nº. 23, 15350 | es |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/69654 | |
dc.description | Producción Científica | es |
dc.description.abstract | Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress in patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution of COVID-19. This is an observational prospective study. The primary endpoint was to analyze the association between lipid peroxidation, lipid, and inflammatory profiles in COVID-19 patients. A multivariate regression analysis was employed. The secondary endpoint included the long-term follow-up of lipid profiles. COVID-19 patients presented significantly lower values in their lipid profile (total, low, and high-density lipoprotein cholesterol) with greater oxidative stress and inflammatory response compared to the healthy controls. Lipid peroxidation was the unique oxidative parameter with a significant association with the total cholesterol (OR: 0.982; 95% CI: 0.969–0.996; p = 0.012), IL1-RA (OR: 0.999; 95% CI: 0.998–0.999; p = 0.021) IL-6 (OR: 1.062; 95% CI: 1.017–1.110; p = 0.007), IL-7 (OR: 0.653; 95% CI: 0.433–0.986; p = 0.042) and IL-17 (OR: 1.098; 95% CI: 1.010–1.193; p = 0.028). Lipid abnormalities recovered after the initial insult during long-term follow-up (IQR 514 days); however, those with high LPO levels at hospital admission had, during long-term follow-up, an atherogenic lipid profile. Our study suggests that oxidative stress in COVID-19 is associated with derangements of the lipid profile and inflammation. Survivors experienced a recovery in their lipid profiles during long-term follow-up, but those with stronger oxidative responses had an atherogenic lipid profile. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cholesterol | es |
dc.subject | Colesterol | es |
dc.subject | Lipoproteins | es |
dc.subject | Lipids | es |
dc.subject | Lipids - Peroxidation | es |
dc.subject | Lípidos | es |
dc.subject | Proteins | es |
dc.subject | Biochemistry | es |
dc.subject | Oxidative stress | es |
dc.subject | Estrés oxidativo | es |
dc.subject | COVID-19 | es |
dc.subject | Inflammation | es |
dc.subject | Inflamación | es |
dc.subject | Medicine | es |
dc.subject | Molecular biology | es |
dc.subject | Dyslipidemia | es |
dc.title | Dyslipidemia and inflammation as hallmarks of oxidative stress in COVID-19: a follow-up study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2022 The authors | es |
dc.identifier.doi | 10.3390/ijms232315350 | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/23/15350 | es |
dc.identifier.publicationfirstpage | 15350 | es |
dc.identifier.publicationissue | 23 | es |
dc.identifier.publicationtitle | International Journal of Molecular Sciences | es |
dc.identifier.publicationvolume | 23 | es |
dc.peerreviewed | SI | es |
dc.description.project | Instituto de Salud Carlos III - (grant CB21/13/00051 and COV20/00491) | es |
dc.description.project | Junta de Castilla y León - (grant 18IGOF) | es |
dc.identifier.essn | 1422-0067 | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
dc.subject.unesco | 2302.27 Proteínas | es |
dc.subject.unesco | 2302 Bioquímica | es |
dc.subject.unesco | 32 Ciencias Médicas | es |
dc.subject.unesco | 2415 Biología Molecular | es |
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