Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/69654
Título
Dyslipidemia and inflammation as hallmarks of oxidative stress in COVID-19: a follow-up study
Autor
Año del Documento
2022
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
International Journal of Molecular Sciences, 2022, Vol. 23, Nº. 23, 15350
Resumen
Recent works have demonstrated a significant reduction in cholesterol levels and increased oxidative stress in patients with coronavirus disease 2019 (COVID-19). The cause of this alteration is not well known. This study aimed to comprehensively evaluate their possible association during the evolution of COVID-19. This is an observational prospective study. The primary endpoint was to analyze the association between lipid peroxidation, lipid, and inflammatory profiles in COVID-19 patients. A multivariate regression analysis was employed. The secondary endpoint included the long-term follow-up of lipid profiles. COVID-19 patients presented significantly lower values in their lipid profile (total, low, and high-density lipoprotein cholesterol) with greater oxidative stress and inflammatory response compared to the healthy controls. Lipid peroxidation was the unique oxidative parameter with a significant association with the total cholesterol (OR: 0.982; 95% CI: 0.969–0.996; p = 0.012), IL1-RA (OR: 0.999; 95% CI: 0.998–0.999; p = 0.021) IL-6 (OR: 1.062; 95% CI: 1.017–1.110; p = 0.007), IL-7 (OR: 0.653; 95% CI: 0.433–0.986; p = 0.042) and IL-17 (OR: 1.098; 95% CI: 1.010–1.193; p = 0.028). Lipid abnormalities recovered after the initial insult during long-term follow-up (IQR 514 days); however, those with high LPO levels at hospital admission had, during long-term follow-up, an atherogenic lipid profile. Our study suggests that oxidative stress in COVID-19 is associated with derangements of the lipid profile and inflammation. Survivors experienced a recovery in their lipid profiles during long-term follow-up, but those with stronger oxidative responses had an atherogenic lipid profile.
Materias (normalizadas)
Cholesterol
Colesterol
Lipoproteins
Lipids
Lipids - Peroxidation
Lípidos
Proteins
Biochemistry
Oxidative stress
Estrés oxidativo
COVID-19
Inflammation
Inflamación
Medicine
Molecular biology
Dyslipidemia
Materias Unesco
2302.27 Proteínas
2302 Bioquímica
32 Ciencias Médicas
2415 Biología Molecular
ISSN
1422-0067
Revisión por pares
SI
Patrocinador
Instituto de Salud Carlos III - (grant CB21/13/00051 and COV20/00491)
Junta de Castilla y León - (grant 18IGOF)
Junta de Castilla y León - (grant 18IGOF)
Version del Editor
Propietario de los Derechos
© 2022 The authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
Aparece en las colecciones
Ficheros en el ítem
![Atribución 4.0 Internacional](/themes/Mirage2//images/creativecommons/cc-by.png)