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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/7091

    Título
    Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting
    Autor
    Cayzac, A.
    Rocher Martín, María AsunciónAutoridad UVA Orcid
    Obeso Cáceres, Ana María de la LuzAutoridad UVA Orcid
    González Martínez, Constancio
    Ricardi, D.
    Kemp, P. K.
    Año del Documento
    2011
    Editorial
    Elsevier
    Descripción
    Innovación Educativa
    Documento Fuente
    Respiratory Physiology & Neurobiology 175 (2011) 80–89
    Resumen
    An increase in intracellular Ca2+ is crucial to O2 sensing by the carotid body. Polyamines have been reported to modulate both the extracellular Ca2+-sensing receptor (CaR) and voltage-gated Ca2+ channels in a number of cell types. Using RT-PCR and immunohistochemistry, the predominant voltage-gated Ca2+ channels expressed in the adult rat carotid body were L (CaV1.2) and N (CaV2.2)-type. CaR mRNA could not be amplified from carotid bodies, but the protein was expressed in the nerve endings. Spermine inhibited the hypoxia-evoked catecholamine release from isolated carotid bodies and attenuated the depolarization- and hypoxia-evoked Ca2+ influx into isolated glomus cells. In agreement with data from carotid body, recombinant CaV1.2 was also inhibited by spermine. In contrast, the positive allosteric modulator of CaR, R-568, was without effect on hypoxia-induced catecholamine release from carotid bodies and depolarization-evoked Ca2+ influx into glomus cells. These data show that spermine exerts a negative influence on carotid body O2 sensing by inhibiting L-type Ca2+ channels.
    Materias (normalizadas)
    Respiración celular
    ISSN
    1569-9048
    Revisión por pares
    Sí
    DOI
    10.1016/j.resp.2010.09.009
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/7091
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [353]
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    Descripción:
    PD-179
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalLa licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

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