Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/7121
Título
Chemoreception in the context of the general biology of ROS
Autor
Año del Documento
2007
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Respiratory Physiology & Neurobiology 157 (2007) 30–44
Zusammenfassung
Superoxide anion is the most important reactive oxygen species (ROS) primarily generated in cells. The main cellular constituents with capabilities
to generate superoxide anion areNADPHoxidases and mitochondrial respiratory chain. The emphasis of our article is centered in critically examining
hypotheses proposing that ROS generated by NADPH oxidase and mitochondria are key elements in O2-sensing and hypoxic responses generation
in carotid body chemoreceptor cells. Available data indicate that chemoreceptor cells express a specific isoform of NADPH oxidase that is activated
by hypoxia; generated ROS acting as negative modulators of the carotid body (CB) hypoxic responses. Literature is also consistent in supporting
that poisoned respiratory chain can produce high amounts of ROS, making mitochondrial ROS potential triggers-modulators of the CB activation
elicited by mitochondrial venoms. However, most data favour the notion that levels of hypoxia, capable of strongly activating chemoreceptor cells,
would not increase the rate of ROS production in mitochondria, making mitochondrial ROS unlikely triggers of hypoxic responses in the CB.
Finally, we review recent literature on heme oxygenases from two perspectives, as potential O2-sensors in chemoreceptor cells and as generators
of bilirubin which is considered to be a ROS scavenger of major quantitative importance in mammalian cells.
Materias (normalizadas)
Respiración celular
ISSN
1569-9048
Revisión por pares
SI
Idioma
eng
Derechos
openAccess
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