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dc.contributor.author | Dinger, Bruce | |
dc.contributor.author | He, Le | |
dc.contributor.author | Chen, J. | |
dc.contributor.author | Liu, X. | |
dc.contributor.author | González, Constancio | |
dc.contributor.author | Obeso Cáceres, Ana María de la Luz | es |
dc.contributor.author | Sanders, K. | |
dc.contributor.author | Hoidal, J. | |
dc.contributor.author | Stensaas, L. | |
dc.contributor.author | Fidone, Salvatore | |
dc.date.accessioned | 2014-11-14T12:01:12Z | |
dc.date.available | 2014-11-14T12:01:12Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Respiratory Physiology & Neurobiology 157 (2007) 45–54 | es |
dc.identifier.issn | 1569-9048 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/7156 | |
dc.description | Producción Científica | es |
dc.description.abstract | O2-sensing in the carotid body occurs in neuroectoderm-derived type I glomus cells where hypoxia elicits a complex chemotransduction cascade involving membrane depolarization, Ca2+ entry and the release of excitatory neurotransmitters. Efforts to understand the exquisite O2-sensitivity of these cells currently focus on the coupling between local PO2 and the open-closed state of K+-channels. Amongst multiple competing hypotheses is the notion that K+-channel activity is mediated by a phagocytic-like multisubunit enzyme, NADPH oxidase, which produces reactive oxygen species (ROS) in proportion to the prevailing PO2. In O2-sensitive cells of lung neuroepithelial bodies (NEB), multiple studies confirm that ROS levels decrease in hypoxia, and that EM and K+-channel activity are indeed controlled by ROS produced by NADPH oxidase. However, recent studies in our laboratories suggest that ROS generated by a non-phagocyte isoform of the oxidase are important contributors to chemotransduction, but that their role in type I cells differs fundamentally from the mechanism utilized by NEB chemoreceptors. Data indicate that in response to hypoxia, NADPH oxidase activity is increased in type I cells, and further, that increased ROS levels generated in response to low-O2 facilitate cell repolarization via specific subsets of K+-channels. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Neurofisiologia | es |
dc.title | The role of NADPH oxidase in carotid body arterial chemoreceptors | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1016/j.resp.2006.12.003 | es |
dc.identifier.publicationfirstpage | 45 | es |
dc.identifier.publicationlastpage | 54 | es |
dc.identifier.publicationtitle | Respiratory Physiology & Neurobiology | es |
dc.identifier.publicationvolume | 157 | es |
dc.peerreviewed | SI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
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