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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/74261

    Título
    Role of Polyamines and cAMP-dependent Mechanisms on 5α-dihydrotestosterone-elicited Functional Effects in Isolated Right Atria of Rat
    Autor
    Sánchez, Manuel
    Secades, Lorena
    Bordallo, Carmen
    Meana González, ClaraAutoridad UVA Orcid
    Rubín, José Manuel
    Cantabrana, Begoña
    Bordallo, Javier
    Año del Documento
    2009
    Documento Fuente
    Journal of Cardiovascular Pharmacology, octubre 2009, vol. 54, n. 4, p. 310-318
    Zusammenfassung
    Androgens produce acute vasodilation of systemic, pulmonary, and coronary arteries in several mammal preparations and increase cardiomyocyte contractility. A decrease of the spontaneous beating of sinoatrial cells has also been described. The aim of this study was to characterize the direct effect of 5a-dihydrotestosterone on the spontaneous chronotropism and inotropism in the same preparation as an approach to establish the effect on cardiac output and their mechanism of action. The effects were studied on isolated right atria of Wistar rats placed in an organ bath in Tyrode solution at 37 C and bubbled with carbogen. In male rats, the acute administration of 5a-dihydrotestosterone, a nonaromatizable derivate of testosterone, elicited a positive inotropism, which was associate with a negative chronotropism. As reported in the left atria, polyamines and b-adrenoceptors played a role in 5a-dihydrotestosterone–elicited positive inotropism because the effect was antagonized by a-difluoromethylornithine, an inhibitor of polyamine synthesis, and atenolol, a b1-adrenoceptor blocker, but not on the negative effect on chronotropism. The androgen increased the sinoatrial node recovery time, suggesting an effect on the mechanisms of spontaneous diastolic depolarization involved in atria pacemaking. These effects of 5a-dihydrotestosterone are not hormonally regulated because they are similarly produced in estrogenized females and gonadectomised male and female rats. These results suggest that the androgen could acutely improve cardiac performance.
    ISSN
    0160-2446
    Revisión por pares
    SI
    DOI
    10.1097/FJC.0b013e3181b6e57f
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/74261
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP55 - Artículos de revista [206]
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    Nombre:
    03. 2009. JCVP. Role of polyamines and cAMP-dependent mechanisms on 5a-DHT-elicited functional effects in isolated right atria of rat.pdf
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