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Título
NADþ protects against EAE by regulating CD4þ T-cell differentiation
Autor
Año del Documento
2014
Editorial
Nature Publish Group
Descripción
Producción Científica
Documento Fuente
Nature Communications, 2014, 5, Article number: 5101
Abstract
CD4(+) T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD(+)) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4(+)IFNγ(+)IL-10(+) T cells and reverses disease progression by restoring tissue integrity via remyelination and neuroregeneration. We show that NAD(+) regulates CD4(+) T-cell differentiation through tryptophan hydroxylase-1 (Tph1), independently of well-established transcription factors. In the presence of NAD(+), the frequency of T-bet(-/-) CD4(+)IFNγ(+) T cells was twofold higher than wild-type CD4(+) T cells cultured in conventional T helper 1 polarizing conditions. Our findings unravel a new pathway orchestrating CD4(+) T-cell differentiation and demonstrate that NAD(+) may serve as a powerful therapeutic agent for the treatment of autoimmune and other diseases.
Materias (normalizadas)
Inmunología
Medicamentos - Investigación
ISSN
2041-1723
Revisión por pares
SI
Idioma
eng
Derechos
openAccess
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