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    • DEP05 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/9824

    Título
    WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function.
    Autor
    Westerberg, Lisa S.
    Fuente García, Miguel Ángel de laAutoridad UVA Orcid
    Wermeling, Fredrik
    Ochs, Hans D.
    Karlsson, Mikael C. I.
    Snapper, Scott B.
    Notarangelo, Luigi D.
    Año del Documento
    2008
    Editorial
    American Society of Hematology
    Descripción
    Producción Científica
    Documento Fuente
    Blood. 2008 Nov 15;112(10):4139-47
    Résumé
    Development of hematopoietic cells depends on a dynamic actin cytoskeleton. Here we demonstrate that expression of the cytoskeletal regulator WASP, mutated in the Wiskott-Aldrich syndrome, provides selective advantage for the development of naturally occurring regulatory T cells, natural killer T cells, CD4(+) and CD8(+) T lymphocytes, marginal zone (MZ) B cells, MZ macrophages, and platelets. To define the relative contribution of MZ B cells and MZ macrophages for MZ development, we generated wild-type and WASP-deficient bone marrow chimeric mice, with full restoration of the MZ. However, even in the presence of MZ macrophages, only 10% of MZ B cells were of WASP-deficient origin. We show that WASP-deficient MZ B cells hyperproliferate in vivo and fail to respond to sphingosine-1-phosphate, a crucial chemoattractant for MZ B-cell positioning. Abnormalities of the MZ compartment in WASP(-/-) mice lead to aberrant uptake of Staphylococcus aureus and to a reduced immune response to TNP-Ficoll. Moreover, WASP-deficient mice have increased levels of "natural" IgM antibodies. Our findings reveal that WASP regulates both development and function of hematopoietic cells. We demonstrate that WASP deficiency leads to an aberrant MZ that may affect responses to blood-borne pathogens and peripheral B-cell tolerance.
    Materias (normalizadas)
    Células hematopoyéticas
    ISSN
    0006-4971
    Revisión por pares
    SI
    DOI
    10.1182/blood-2008-02-140715
    Idioma
    spa
    URI
    http://uvadoc.uva.es/handle/10324/9824
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP05 - Artículos de revista [198]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

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