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    • PRODUCCIÓN CIENTÍFICA
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    • Dpto. Biología Celular, Genética, Histología y Farmacología
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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/9838

    Título
    WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1a
    Autor
    Gallego, María Dolores
    Fuente García, Miguel Ángel de laAutoridad UVA Orcid
    Antón, Inés María
    Snapper, Scott B.
    Fuhlbrigge, Robert
    Geha, Raif S.
    Año del Documento
    2005
    Editorial
    Oxford University Press
    Descripción
    Producción Científica
    Documento Fuente
    International Immunology, 2005, vol. 18, n. 2, p. 221-232
    Resumen
    Homing of lymphocytes to tissues is a biologically important multistep process that involves selectindependent rolling, integrin-dependent adhesion and chemokine-directed chemotaxis. The actin cytoskeleton plays a central role in lymphocyte adhesion and motility. Wiskott–Aldrich syndrome protein (WASP), the product of the gene mutated in Wiskott–Aldrich syndrome, and its partner, the Wiskott–Aldrich syndrome protein-interacting protein (WIP), play important roles in actin re-organization in T lymphocytes. We used mice with disruption of the WASP and WIP genes to examine the role of WASP and WIP in T cell homing. T cell homing to spleen and lymph nodes in vivo was deficient in WASP / and WIP / mice and severely impaired in WASP / WIP / double knockout (DKO) mice. Deficiency of WASP, WIP or both did not interfere with selectin-dependent rolling or integrin-dependent adhesion of T cells in vitro. Chemotaxis to stromal cell-derived factor-1a (SDF-1a) in vitro was mildly reduced in T cells from WASP / mice. In contrast, it was significantly impaired in T cells from WIP / mice and severely reduced in T cells from DKO mice. Cellular F-actin increase following SDF-1a stimulation was normal in WASP / and WIP / T cells, but severely reduced in T cells from DKO mice. Actin re-organization and polarization in response to SDF-1a was abnormal in T cells from all knockout mice. Early biochemical events following SDF-1a stimulation that are important for chemotaxis and that included phosphorylation of Lck, cofilin, PAK1 and extracellular regulated kinase (Erk) and GTP loading of Rac-1 were examined in T cells from DKO mice and found to be normal. These results suggest that WASP and WIP are not essential for T lymphocyte rolling and adhesion, but play important and partially redundant roles in T cell chemotaxis in vitro and homing in vivo and function downstream of small GTPases.
    Materias (normalizadas)
    Biología celular
    ISSN
    0953-8178
    Revisión por pares
    SI
    DOI
    10.1093/intimm/dxh310
    Version del Editor
    https://academic.oup.com/intimm/article/18/2/221/664515
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/9838
    Derechos
    openAccess
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    • DEP05 - Artículos de revista [198]
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