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Title: Use of Vibrio cholerae Vaccine in an Outbreak in Guinea
Authors: Luquero, Francisco J.
Grout, Lise
Ciglenecki, Iza
Sakoba, Keita
Traore, Bala
Heile, Melat
Diallo, Alpha Amadou
Itama, Christian
Page, Anne-Laure
Quilici, Marie-Laure
Mengel, Martin A.
Eiros Bouza, José María
Serafini, Micaela
Legros, Dominique
Grais, Rebecca F.
Issue Date: 2014
Publisher: Massachusetts Medical Society
Description: Producción Científica
Citation: New England Journal of Medicine, 2014, vol. 370(22): 2111-2120
Abstract: The use of vaccines to prevent and control cholera is currently under debate. Shanchol is one of the two oral cholera vaccines prequalified by the World Health Organization; however, its effectiveness under field conditions and the protection it confers in the first months after administration remain unknown. The main objective of this study was to estimate the short-term effectiveness of two doses of Shanchol used as a part of the integrated response to a cholera outbreak in Africa. METHODS We conducted a matched case-control study in Guinea between May 20 and October 19, 2012. Suspected cholera cases were confirmed by means of a rapid test, and controls were selected among neighbors of the same age and sex as the case patients. The odds of vaccination were compared between case patients and controls in bivariate and adjusted conditional logistic-regression models. Vaccine effectiveness was calculated as (1-odds ratio) × 100. RESULTS Between June 8 and October 19, 2012, we enrolled 40 case patients and 160 controls in the study for the primary analysis. After adjustment for potentially confounding variables, vaccination with two complete doses was associated with significant protection against cholera (effectiveness, 86.6%; 95% confidence interval, 56.7 to 95.8; P=0.001). CONCLUSIONS In this study, Shanchol was effective when used in response to a cholera outbreak in Guinea. This study provides evidence supporting the addition of vaccination as part of the response to an outbreak. It also supports the ongoing efforts to establish a cholera vaccine stockpile for emergency use, which would enhance outbreak prevention and control strategies.
Keywords: Cólera - Vacunas
ISSN: 0028-4793
Peer Review: SI
DOI: 10.1056/NEJMoa1312680
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP03 - Artículos de revista

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