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Título: Protective effects of epoxypukalide on pancreatic b-cells and glucose metabolism in STZ-induced diabetic mice
Autor: López-Acosta, José F.
Villa-Pérez, Pablo
Fernández-Díaz, Cristina M.
de Luis Román, Daniel
Díaz-Marrero, Ana R.
Cueto, Mercedes
Perdomo, Germán
Cózar-Castellano, Irene
Año del Documento: 2015
Editorial: Taylor & Francis
Descripción: Producción Científica
Documento Fuente: Islets,(2015);7(2):e1078053
Resumen: Diabetes is a consequence of a decrease on functional β-cell mass. We have recently demonstrated that epoxypukalide (Epoxy) is a natural compound with beneficial effects on primary cultures of rat islets. In this study, we extend our previous investigations to test the hypothesis that Epoxy protects β-cells and improves glucose metabolism in STZ-induced diabetic mice. We used 3-months old male mice that were treated with Epoxy at 200 μg/kg body weight. Glucose intolerance was induced by multiple intraperitoneal low-doses of streptozotocin (STZ) on 5 consecutive days. Glucose homeostasis was evaluated measuring plasma insulin levels and glucose tolerance. Histomorphometry was used to quantify the number of pancreatic β-cells per islet. β-cell proliferation was assessed by BrdU incorporation, and apoptosis by TUNEL staining. Epoxy treatment significantly improved glucose tolerance and plasma insulin levels. These metabolic changes were associated with increased β-cell numbers, as a result of a two-fold increase in β-cell proliferation and a 50% decrease in β-cell death. Our results demonstrate that Epoxy improves whole-body glucose homeostasis by preventing pancreatic β-cell death due to STZ-induced toxicity in STZ-treated mice
Materias (normalizadas): Diabetes - Tratamiento
ISSN: 1938-2014
Revisión por Pares: SI
DOI: 10.1080/19382014.2015.1078053
Idioma: eng
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:DEP06 - Artículos de revista

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