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Title: Supported bifunctional thioureas as recoverable and reusable catalysts for enantioselective nitro-Michael reactions
Authors: Andrés García, José María
Ceballos, Miriam
Maestro Fernández, Alicia
Sanz, Isabel
Pedrosa Sáez, Rafael
Issue Date: 2016
Publisher: Beilstein-Institut
Description: Producción Científica
Citation: Beilstein Journal of Organic Chemistry, 2016, 12, p. 628–635
Abstract: The catalytic activity of different supported bifunctional thioureas on sulfonylpolystyrene resins has been studied in the nitro- Michael addition of different nucleophiles to trans-β-nitrostyrene derivatives. The activity of the catalysts depends on the length of the tether linking the chiral thiourea to the polymer. The best results were obtained with the thiourea derived from (L)-valine and 1,6-hexanediamine. The catalysts can be used in only 2 mol % loading, and reused for at least four cycles in neat conditions. The ball milling promoted additions also worked very well.
Keywords: Catalizadores
ISSN: 1860-5397
Peer Review: SI
DOI: 10.3762/bjoc.12.61
Sponsor: Ministerio de Economía, Industria y Competitividad (CTQ2014-59870-P)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA064U13)
Language: eng
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:DEP67 - Artículos de revista

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